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A new lot sizing and scheduling heuristic for multi-site biopharmaceutical production

Author

Listed:
  • Folarin B. Oyebolu

    (University of Warwick)

  • Jeroen Lidth de Jeude

    (University of Warwick)

  • Cyrus Siganporia

    (University College London)

  • Suzanne S. Farid

    (University College London)

  • Richard Allmendinger

    (University of Manchester)

  • Juergen Branke

    (University of Warwick)

Abstract

Biopharmaceutical manufacturing requires high investments and long-term production planning. For large biopharmaceutical companies, planning typically involves multiple products and several production facilities. Production is usually done in batches with a substantial set-up cost and time for switching between products. The goal is to satisfy demand while minimising manufacturing, set-up and inventory costs. The resulting production planning problem is thus a variant of the capacitated lot-sizing and scheduling problem, and a complex combinatorial optimisation problem. Inspired by genetic algorithm approaches to job shop scheduling, this paper proposes a tailored construction heuristic that schedules demands of multiple products sequentially across several facilities to build a multi-year production plan (solution). The sequence in which the construction heuristic schedules the different demands is optimised by a genetic algorithm. We demonstrate the effectiveness of the approach on a biopharmaceutical lot sizing problem and compare it with a mathematical programming model from the literature. We show that the genetic algorithm can outperform the mathematical programming model for certain scenarios because the discretisation of time in mathematical programming artificially restricts the solution space.

Suggested Citation

  • Folarin B. Oyebolu & Jeroen Lidth de Jeude & Cyrus Siganporia & Suzanne S. Farid & Richard Allmendinger & Juergen Branke, 2017. "A new lot sizing and scheduling heuristic for multi-site biopharmaceutical production," Journal of Heuristics, Springer, vol. 23(4), pages 231-256, August.
    • Handle: RePEc:spr:joheur:v:23:y:2017:i:4:d:10.1007_s10732-017-9338-9
    DOI: 10.1007/s10732-017-9338-9
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    References listed on IDEAS

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    1. Almeder, Christian, 2010. "A hybrid optimization approach for multi-level capacitated lot-sizing problems," European Journal of Operational Research, Elsevier, vol. 200(2), pages 599-606, January.
    2. Harvey M. Wagner & Thomson M. Whitin, 1958. "Dynamic Version of the Economic Lot Size Model," Management Science, INFORMS, vol. 5(1), pages 89-96, October.
    3. Gabriel R. Bitran & Horacio H. Yanasse, 1982. "Computational Complexity of the Capacitated Lot Size Problem," Management Science, INFORMS, vol. 28(10), pages 1174-1186, October.
    4. Edmund K Burke & Michel Gendreau & Matthew Hyde & Graham Kendall & Gabriela Ochoa & Ender Özcan & Rong Qu, 2013. "Hyper-heuristics: a survey of the state of the art," Journal of the Operational Research Society, Palgrave Macmillan;The OR Society, vol. 64(12), pages 1695-1724, December.
    5. Ravi Ramya & Chandrasekharan Rajendran & Hans Ziegler, 2016. "Capacitated lot-sizing problem with production carry-over and set-up splitting: mathematical models," International Journal of Production Research, Taylor & Francis Journals, vol. 54(8), pages 2332-2344, April.
    6. Jans, Raf & Degraeve, Zeger, 2007. "Meta-heuristics for dynamic lot sizing: A review and comparison of solution approaches," European Journal of Operational Research, Elsevier, vol. 177(3), pages 1855-1875, March.
    7. Karina Copil & Martin Wörbelauer & Herbert Meyr & Horst Tempelmeier, 2017. "Simultaneous lotsizing and scheduling problems: a classification and review of models," OR Spectrum: Quantitative Approaches in Management, Springer;Gesellschaft für Operations Research e.V., vol. 39(1), pages 1-64, January.
    8. Ozdamar, Linet & Birbil, Sevket Ilker, 1998. "Hybrid heuristics for the capacitated lot sizing and loading problem with setup times and overtime decisions," European Journal of Operational Research, Elsevier, vol. 110(3), pages 525-547, November.
    9. J C Ho & Y-L Chang & A O Solis, 2006. "Two modifications of the least cost per period heuristic for dynamic lot-sizing," Journal of the Operational Research Society, Palgrave Macmillan;The OR Society, vol. 57(8), pages 1005-1013, August.
    10. Drexl, A. & Kimms, A., 1997. "Lot sizing and scheduling -- Survey and extensions," European Journal of Operational Research, Elsevier, vol. 99(2), pages 221-235, June.
    11. Karimi, B. & Fatemi Ghomi, S. M. T. & Wilson, J. M., 2003. "The capacitated lot sizing problem: a review of models and algorithms," Omega, Elsevier, vol. 31(5), pages 365-378, October.
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    Cited by:

    1. Dziuba, Daryna & Almeder, Christian, 2023. "New construction heuristic for capacitated lot sizing problems," European Journal of Operational Research, Elsevier, vol. 311(3), pages 906-920.
    2. Sahling, Florian & Hahn, Gerd J., 2019. "Dynamic lot sizing in biopharmaceutical manufacturing," International Journal of Production Economics, Elsevier, vol. 207(C), pages 96-106.

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