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Methodological considerations in cost of illness studies on Alzheimer disease

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Listed:
  • Nagede Costa
  • Helene Derumeaux
  • Thomas Rapp
  • Valérie Garnault
  • Laura Ferlicoq
  • Sophie Gillette
  • Sandrine Andrieu
  • Bruno Vellas
  • Michel Lamure
  • Alain Grand
  • Laurent Molinier

Abstract

Cost-of-illness studies (COI) can identify and measure all the costs of a particular disease, including the direct, indirect and intangible dimensions. They are intended to provide estimates about the economic impact of costly disease. Alzheimer disease (AD) is a relevant example to review cost of illness studies because of its costliness.The aim of this study was to review relevant published cost studies of AD to analyze the method used and to identify which dimension had to be improved from a methodological perspective. First, we described the key points of cost study methodology. Secondly, cost studies relating to AD were systematically reviewed, focussing on an analysis of the different methods used. The methodological choices of the studies were analysed using an analytical grid which contains the main methodological items of COI studies. Seventeen articles were retained. Depending on the studies, annual total costs per patient vary from $2,935 to $52, 954. The methods, data sources, and estimated cost categories in each study varied widely. The review showed that cost studies adopted different approaches to estimate costs of AD, reflecting a lack of consensus on the methodology of cost studies. To increase its credibility, closer agreement among researchers on the methodological principles of cost studies would be desirable. Copyright Costa et al.; licensee Springer. 2012

Suggested Citation

  • Nagede Costa & Helene Derumeaux & Thomas Rapp & Valérie Garnault & Laura Ferlicoq & Sophie Gillette & Sandrine Andrieu & Bruno Vellas & Michel Lamure & Alain Grand & Laurent Molinier, 2012. "Methodological considerations in cost of illness studies on Alzheimer disease," Health Economics Review, Springer, vol. 2(1), pages 1-12, December.
    • Handle: RePEc:spr:hecrev:v:2:y:2012:i:1:p:1-12:10.1186/2191-1991-2-18
    DOI: 10.1186/2191-1991-2-18
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    1. Tarricone, Rosanna, 2006. "Cost-of-illness analysis: What room in health economics?," Health Policy, Elsevier, vol. 77(1), pages 51-63, June.
    2. van den Berg, Bernard & Brouwer, Werner & van Exel, Job & Koopmanschap, Marc & van den Bos, Geertrudis A.M. & Rutten, Frans, 2006. "Economic valuation of informal care: Lessons from the application of the opportunity costs and proxy good methods," Social Science & Medicine, Elsevier, vol. 62(4), pages 835-845, February.
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    1. Neubert, Lydia & König, Hans-Helmut & Löbner, Margrit & Luppa, Melanie & Pentzek, Michael & Fuchs, Angela & Weeg, Dagmar & Bickel, Horst & Oey, Anke & Wiese, Birgitt & Weyerer, Siegfried & Werle, Joch, 2021. "Excess costs of dementia in old age (85+) in Germany: Results from the AgeCoDe-AgeQualiDe study," The Journal of the Economics of Ageing, Elsevier, vol. 20(C).
    2. Lili Wang & Lei Si & Fiona Cocker & Andrew J. Palmer & Kristy Sanderson, 2018. "A Systematic Review of Cost-of-Illness Studies of Multimorbidity," Applied Health Economics and Health Policy, Springer, vol. 16(1), pages 15-29, February.
    3. T. Joseph Mattingly & R. Brett McQueen & Pei-Jung Lin, 2021. "Contextual Considerations and Recommendations for Estimating the Value of Alzheimer’s Disease Therapies," PharmacoEconomics, Springer, vol. 39(10), pages 1101-1107, October.
    4. Huajie Jin & Paul McCrone, 2015. "Cost-of-Illness Studies for Bipolar Disorder: Systematic Review of International Studies," PharmacoEconomics, Springer, vol. 33(4), pages 341-353, April.
    5. Jeroen T J M van Dijck & Mark D Dijkman & Robbin H Ophuis & Godard C W de Ruiter & Wilco C Peul & Suzanne Polinder, 2019. "In-hospital costs after severe traumatic brain injury: A systematic review and quality assessment," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-21, May.
    6. Rebecca Addo & Samuel Agyei Agyemang & Yesim Tozan & Justice Nonvignon, 2018. "Economic burden of caregiving for persons with severe mental illness in sub-Saharan Africa: A systematic review," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-12, August.
    7. Margherita d’Errico & Milena Pavlova & Federico Spandonaro, 2022. "The economic burden of obesity in Italy: a cost-of-illness study," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 23(2), pages 177-192, March.

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