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Can the Direct Medical Cost of Chronic Disease Be Transferred across Different Countries? Using Cost-of-Illness Studies on Type 2 Diabetes, Epilepsy and Schizophrenia as Examples

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  • Lan Gao
  • Hao Hu
  • Fei-Li Zhao
  • Shu-Chuen Li

Abstract

Objectives: To systematically review cost of illness studies for schizophrenia (SC), epilepsy (EP) and type 2 diabetes mellitus (T2DM) and explore the transferability of direct medical cost across countries. Methods: A comprehensive literature search was performed to yield studies that estimated direct medical costs. A generalized linear model (GLM) with gamma distribution and log link was utilized to explore the variation in costs that accounted by the included factors. Both parametric (Random-effects model) and non-parametric (Boot-strapping) meta-analyses were performed to pool the converted raw cost data (expressed as percentage of GDP/capita of the country where the study was conducted). Results: In total, 93 articles were included (40 studies were for T2DM, 34 studies for EP and 19 studies for SC). Significant variances were detected inter- and intra-disease classes for the direct medical costs. Multivariate analysis identified that GDP/capita (p

Suggested Citation

  • Lan Gao & Hao Hu & Fei-Li Zhao & Shu-Chuen Li, 2016. "Can the Direct Medical Cost of Chronic Disease Be Transferred across Different Countries? Using Cost-of-Illness Studies on Type 2 Diabetes, Epilepsy and Schizophrenia as Examples," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-17, January.
    • Handle: RePEc:plo:pone00:0147169
    DOI: 10.1371/journal.pone.0147169
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    References listed on IDEAS

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    2. Yi-Jun Liu & Adam Keane & Kate T Simms & Jie-Bin Lew & Ju-Fang Shi & Carolyn Mazariego & Susan Yuill & Jose Jeronimo & You-Lin Qiao & Karen Canfell, 2019. "Development and application of a framework to estimate health care costs in China: The cervical cancer example," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-13, October.

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