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Investigation of a protein complex network

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  • A. Mashaghi
  • A. Ramezanpour
  • V. Karimipour

Abstract

The budding yeast Saccharomyces cerevisiae is the first eukaryote whose genome has been completely sequenced. It is also the first eukaryotic cell whose proteome (the set of all proteins) and interactome (the network of all mutual interactions between proteins) has been analyzed. In this paper we study the structure of the yeast protein complex network in which weighted edges between complexes represent the number of shared proteins. It is found that the network of protein complexes is a small world network with scale free behavior for many of its distributions. However we find that there are no strong correlations between the weights and degrees of neighboring complexes. To reveal non-random features of the network we also compare it with a null model in which the complexes randomly select their proteins. Finally we propose a simple evolutionary model based on duplication and divergence of proteins. Copyright Springer-Verlag Berlin/Heidelberg 2004

Suggested Citation

  • A. Mashaghi & A. Ramezanpour & V. Karimipour, 2004. "Investigation of a protein complex network," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 41(1), pages 113-121, September.
    • Handle: RePEc:spr:eurphb:v:41:y:2004:i:1:p:113-121
    DOI: 10.1140/epjb/e2004-00301-0
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    References listed on IDEAS

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    1. Dorogovtsev, S.N. & Mendes, J.F.F., 2003. "Evolution of Networks: From Biological Nets to the Internet and WWW," OUP Catalogue, Oxford University Press, number 9780198515906.
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    2. Du, Xiangjun & Shao, Fengjing & Wu, Shunyao & Sun, Rencheng & Wang, Changying, 2017. "Complex network modeling for mechanisms of red tide occurrence: A case study in Bohai Sea and North Yellow Sea of China," Ecological Modelling, Elsevier, vol. 361(C), pages 41-48.

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