IDEAS home Printed from https://ideas.repec.org/a/spr/drugsa/v42y2019i12d10.1007_s40264-019-00866-7.html
   My bibliography  Save this article

Comparative Effectiveness and Safety of Direct Oral Anticoagulants: Overview of Systematic Reviews

Author

Listed:
  • Emanuel Raschi

    (University of Bologna)

  • Matteo Bianchin

    (University of Bologna)

  • Milo Gatti

    (University of Bologna)

  • Alessandro Squizzato

    (University of Insubria)

  • Fabrizio De Ponti

    (University of Bologna)

Abstract

Direct oral anticoagulants are now recommended by major guidelines as first-choice agents for both stroke prevention in non-valvular atrial fibrillation and treatment/prevention of venous thromboembolism in non-cancer patients. Although there are no published head-to-head trials comparing different direct oral anticoagulants, a growing body of evidence from indirect comparisons and observational studies is suggesting that each direct oral anticoagulant may have a specific risk profile. This review aims to (1) synthesize and critically assess the latest evidence in comparative effectiveness and safety research in the aforementioned consolidated therapeutic uses, by performing an overview of systematic reviews and (2) highlight current challenges, namely underexplored areas, where research should be directed, also considering ongoing unpublished studies. The evidence gathered so far on the risk–benefit profile of direct oral anticoagulants is appraised in the light of existing guidelines to discuss whether further implementation should be proposed.

Suggested Citation

  • Emanuel Raschi & Matteo Bianchin & Milo Gatti & Alessandro Squizzato & Fabrizio De Ponti, 2019. "Comparative Effectiveness and Safety of Direct Oral Anticoagulants: Overview of Systematic Reviews," Drug Safety, Springer, vol. 42(12), pages 1409-1422, December.
    • Handle: RePEc:spr:drugsa:v:42:y:2019:i:12:d:10.1007_s40264-019-00866-7
    DOI: 10.1007/s40264-019-00866-7
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40264-019-00866-7
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s40264-019-00866-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Guillermo Prada-Ramallal & Bahi Takkouche & Adolfo Figueiras, 2017. "Summarising the Evidence for Drug Safety: A Methodological Discussion of Different Meta-Analysis Approaches," Drug Safety, Springer, vol. 40(7), pages 547-558, July.
    2. Patricia McGettigan & Carla Alonso Olmo & Kelly Plueschke & Mireia Castillon & Daniel Nogueras Zondag & Priya Bahri & Xavier Kurz & Peter G. M. Mol, 2019. "Patient Registries: An Underused Resource for Medicines Evaluation," Drug Safety, Springer, vol. 42(11), pages 1343-1351, November.
    3. John Leonard Fitzgerald & Laurence Guy Howes, 2016. "Drug Interactions of Direct-Acting Oral Anticoagulants," Drug Safety, Springer, vol. 39(9), pages 841-845, September.
    4. Géric Maura & Cécile Billionnet & Joël Coste & Alain Weill & Anke Neumann & Antoine Pariente, 2018. "Non-bleeding Adverse Events with the Use of Direct Oral Anticoagulants: A Sequence Symmetry Analysis," Drug Safety, Springer, vol. 41(9), pages 881-897, September.
    5. Emanuel Raschi & Matteo Bianchin & Walter Ageno & Roberto De Ponti & Fabrizio De Ponti, 2016. "Risk–Benefit Profile of Direct-Acting Oral Anticoagulants in Established Therapeutic Indications: An Overview of Systematic Reviews and Observational Studies," Drug Safety, Springer, vol. 39(12), pages 1175-1187, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Emanuel Raschi & Matteo Bianchin & Walter Ageno & Roberto De Ponti & Fabrizio De Ponti, 2016. "Risk–Benefit Profile of Direct-Acting Oral Anticoagulants in Established Therapeutic Indications: An Overview of Systematic Reviews and Observational Studies," Drug Safety, Springer, vol. 39(12), pages 1175-1187, December.
    2. Rita Francisco & Sandra Brasil & Carlota Pascoal & Andrew C. Edmondson & Jaak Jaeken & Paula A. Videira & Cláudia de Freitas & Vanessa dos Reis Ferreira & Dorinda Marques-da-Silva, 2022. "A Community-Led Approach as a Guide to Overcome Challenges for Therapy Research in Congenital Disorders of Glycosylation," IJERPH, MDPI, vol. 19(11), pages 1-19, June.
    3. Ravi Jandhyala, 2019. "Comment on: “Patient Registries: An Underused Resource for Medicines Evaluation: Operational Proposals for Increasing the Use of Patient Registries in Regulatory Assessments”," Drug Safety, Springer, vol. 42(12), pages 1515-1516, December.
    4. Kamila Sienkiewicz & Monika Burzyńska & Izabela Rydlewska-Liszkowska & Jacek Sienkiewicz & Ewelina Gaszyńska, 2021. "The Importance of Direct Patient Reporting of Adverse Drug Reactions in the Safety Monitoring Process," IJERPH, MDPI, vol. 19(1), pages 1-16, December.
    5. Patricia McGettigan & Carla Alonso Olmo & Kelly Plueschke & Mireia Castillon & Daniel Zondag & Priya Bahri & Xavier Kurz & Peter G. M. Mol, 2019. "Authors’ Reply to Ravi Jandhyala’s Comment on “Patient Registries: An Underused Resource for Medicines Evaluation: Operational Proposals for Increasing the Use of Patient Registries in Regulatory Asse," Drug Safety, Springer, vol. 42(12), pages 1517-1518, December.
    6. Géric Maura & Cécile Billionnet & Joël Coste & Alain Weill & Anke Neumann & Antoine Pariente, 2018. "Non-bleeding Adverse Events with the Use of Direct Oral Anticoagulants: A Sequence Symmetry Analysis," Drug Safety, Springer, vol. 41(9), pages 881-897, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:drugsa:v:42:y:2019:i:12:d:10.1007_s40264-019-00866-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com/economics/journal/40264 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.