IDEAS home Printed from https://ideas.repec.org/a/sae/medema/v34y2014i7p899-910.html
   My bibliography  Save this article

A Bayesian Mixed-Treatment Comparison Meta-analysis of Treatments for Alcohol Dependence and Implications for Planning Future Trials

Author

Listed:
  • Stacia M. DeSantis
  • Huirong Zhu

Abstract

Background. Several treatments for alcohol dependence have been tested in randomized controlled trials, giving rise to systematic reviews with a network of evidence structure, or mixed treatment comparisons (MTCs). Within the network, there are few direct comparisons of active treatments. Thus far, this network has not been adequately analyzed. For example, “indirect comparisons†between treatments (e.g., the comparison of treatments B:C obtained via estimates from A:B and A:C trials) have not been incorporated into estimates of treatment effects. This has implications for the planning of future randomized controlled trials. Methods. We applied recent developments in Bayesian MTC meta-analysis to analyze the network of evidence. Using these results, we proposed a methodology to inform, design, and power a hypothetical trial in the context of an updated meta-analysis for treatments that have been infrequently compared and therefore whose effect sizes are not well informed by a meta-analysis. Results. An MTC meta-analysis provides more accurate estimates than a pairwise meta-analysis and uncovers decisive differences between active treatments that have been infrequently directly compared. Weighting across all outcomes indicates that a combination (naltrexone + acamprosate) treatment has the highest posterior probability of being the “best†treatment. If a new clinical trial were to be conducted of a combination therapy versus acamprosate alone, there is no feasible sample size that would result in a decisive meta-analysis. Conclusions. An MTC meta-analysis should be used to estimate treatment effects in networks in which direct and indirect evidence are consistent and to inform the design of future studies.

Suggested Citation

  • Stacia M. DeSantis & Huirong Zhu, 2014. "A Bayesian Mixed-Treatment Comparison Meta-analysis of Treatments for Alcohol Dependence and Implications for Planning Future Trials," Medical Decision Making, , vol. 34(7), pages 899-910, October.
    • Handle: RePEc:sae:medema:v:34:y:2014:i:7:p:899-910
    DOI: 10.1177/0272989X14537558
    as

    Download full text from publisher

    File URL: https://journals.sagepub.com/doi/10.1177/0272989X14537558
    Download Restriction: no
    File URL: https://libkey.io/10.1177/0272989X14537558?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. David J. Spiegelhalter & Nicola G. Best & Bradley P. Carlin & Angelika Van Der Linde, 2002. "Bayesian measures of model complexity and fit," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 64(4), pages 583-639, October.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Rebecca Graziani & Sergio Venturini, 2020. "A Bayesian approach to discrete multiple outcome network meta-analysis," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-17, April.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Buddhavarapu, Prasad & Bansal, Prateek & Prozzi, Jorge A., 2021. "A new spatial count data model with time-varying parameters," Transportation Research Part B: Methodological, Elsevier, vol. 150(C), pages 566-586.
    2. Mumtaz, Haroon & Theodoridis, Konstantinos, 2017. "Common and country specific economic uncertainty," Journal of International Economics, Elsevier, vol. 105(C), pages 205-216.
    3. Christina Leuker & Thorsten Pachur & Ralph Hertwig & Timothy J. Pleskac, 2019. "Do people exploit risk–reward structures to simplify information processing in risky choice?," Journal of the Economic Science Association, Springer;Economic Science Association, vol. 5(1), pages 76-94, August.
    4. Rubio, F.J. & Steel, M.F.J., 2011. "Inference for grouped data with a truncated skew-Laplace distribution," Computational Statistics & Data Analysis, Elsevier, vol. 55(12), pages 3218-3231, December.
    5. Alessandri, Piergiorgio & Mumtaz, Haroon, 2019. "Financial regimes and uncertainty shocks," Journal of Monetary Economics, Elsevier, vol. 101(C), pages 31-46.
    6. Svetlana V. Tishkovskaya & Paul G. Blackwell, 2021. "Bayesian estimation of heterogeneous environments from animal movement data," Environmetrics, John Wiley & Sons, Ltd., vol. 32(6), September.
    7. Leonardo Oliveira Martins & Hirohisa Kishino, 2010. "Distribution of distances between topologies and its effect on detection of phylogenetic recombination," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 62(1), pages 145-159, February.
    8. Tamal Ghosh & Malay Ghosh & Jerry J. Maples & Xueying Tang, 2022. "Multivariate Global-Local Priors for Small Area Estimation," Stats, MDPI, vol. 5(3), pages 1-16, July.
    9. Eibich, Peter & Ziebarth, Nicolas, 2014. "Examining the Structure of Spatial Health Effects in Germany Using Hierarchical Bayes Models," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, vol. 49, pages 305-320.
    10. Wu, Ji & Guo, Mengmeng & Chen, Minghua & Jeon, Bang Nam, 2019. "Market power and risk-taking of banks: Some semiparametric evidence from emerging economies," Emerging Markets Review, Elsevier, vol. 41(C).
    11. repec:jss:jstsof:21:i08 is not listed on IDEAS
    12. Deng, Yaguo, 2016. "Efficiency evaluation of Spanish hotel chains," DES - Working Papers. Statistics and Econometrics. WS 23897, Universidad Carlos III de Madrid. Departamento de Estadística.
    13. Cathy W. S. Chen & Sangyeol Lee, 2017. "Bayesian causality test for integer-valued time series models with applications to climate and crime data," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 66(4), pages 797-814, August.
    14. Makoto Chikaraishi & Akimasa Fujiwara & Junyi Zhang & Kay Axhausen, 2011. "Identifying variations and co-variations in discrete choice models," Transportation, Springer, vol. 38(6), pages 993-1016, November.
    15. Galatia Cleanthous & Emilio Porcu & Philip White, 2021. "Regularity and approximation of Gaussian random fields evolving temporally over compact two-point homogeneous spaces," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 30(4), pages 836-860, December.
    16. Baños-Pino, José F. & Boto-García, David & Zapico, Emma, 2021. "Persistence and dynamics in the efficiency of toll motorways: The Spanish case," Efficiency Series Papers 2021/03, University of Oviedo, Department of Economics, Oviedo Efficiency Group (OEG).
    17. Xing Ju Lee & Christopher C. Drovandi & Anthony N. Pettitt, 2015. "Model choice problems using approximate Bayesian computation with applications to pathogen transmission data sets," Biometrics, The International Biometric Society, vol. 71(1), pages 198-207, March.
    18. Chaix, Basile & Jouven, Xavier & Thomas, Frédérique & Leal, Cinira & Billaudeau, Nathalie & Bean, Kathy & Kestens, Yan & Jëgo, Bertrand & Pannier, Bruno & Danchin, Nicolas, 2011. "Why socially deprived populations have a faster resting heart rate: Impact of behaviour, life course anthropometry, and biology – the RECORD Cohort Study," Social Science & Medicine, Elsevier, vol. 73(10), pages 1543-1550.
    19. Emilio Augusto Coelho-Barros & Jorge Alberto Achcar & Josmar Mazucheli, 2010. "Longitudinal Poisson modeling: an application for CD4 counting in HIV-infected patients," Journal of Applied Statistics, Taylor & Francis Journals, vol. 37(5), pages 865-880.
    20. Mayer Alvo & Jingrui Mu, 2023. "COVID-19 Data Analysis Using Bayesian Models and Nonparametric Geostatistical Models," Mathematics, MDPI, vol. 11(6), pages 1-13, March.
    21. Ye, Mao & Lu, Zhao-Hua & Li, Yimei & Song, Xinyuan, 2019. "Finite mixture of varying coefficient model: Estimation and component selection," Journal of Multivariate Analysis, Elsevier, vol. 171(C), pages 452-474.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:sae:medema:v:34:y:2014:i:7:p:899-910. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: SAGE Publications (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.