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Neoadjuvant immunotherapy for resectable esophageal cancer: A protocol of meta-analysis

Author

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  • Guocan Yu
  • Wenfeng Yu
  • Xudong Xu
  • Bo Ye
  • Liwei Yao

Abstract

Background: Esophageal cancer is a highly malignant cancer with a very poor prognosis. For resectable esophageal cancer, neoadjuvant treatment could improve the prognosis of esophageal cancer. However, current clinical neoadjuvant treatment options for esophageal cancer are still limited. The application of immunotherapy is a potentially beneficial new neoadjuvant treatment option for esophageal cancer. The objective of this meta-analysis is to evaluate the efficacy and safety of immunotherapy for the neoadjuvant treatment of esophageal cancer. Methods: We will search Wanfang Database, SinoMed, China National Knowledge Infrastructure, Embase, Web of Science, Pubmed, and Cochrane Library for relevant articles published before July, 2021. We will also search the unpublished clinical trials of neoadjuvant immunotherapy in esophageal cancer in preprint website (such as bioRXiv and medRxiv) up to July, 2021. We will perform a meta-analysis to evaluate the efficacy and safety of neoadjuvant immunotherapy for resectable esophageal cancer. Randomized controlled trials (RCTs) will be included in this study. The risk of bias will be evaluated for each included study using the Cochrane Handbook for Systematic Reviews of Interventions. We will use RevMan 5.3 software for statistical analysis of the data. Results: The results of this study will provide evidence of immunotherapy using as neoadjuvant treatment for esophageal cancer. This meta-analysis will be submitted to a peer-reviewed journal seeking for publication. Conclusion: The results of this study will provide a reliable basis for clinicians and patients to formulate the best pre-surgical treatment plan for resectable esophageal cancer. Systematic review registration: INPLASY202120026.

Suggested Citation

  • Guocan Yu & Wenfeng Yu & Xudong Xu & Bo Ye & Liwei Yao, 2021. "Neoadjuvant immunotherapy for resectable esophageal cancer: A protocol of meta-analysis," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0252829
    DOI: 10.1371/journal.pone.0252829
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    References listed on IDEAS

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    3. Guocan Yu & Wuchen Zhao & Yanqin Shen & Pengfei Zhu & Hong Zheng, 2020. "Metagenomic next generation sequencing for the diagnosis of tuberculosis meningitis: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-12, December.
    4. Guocan Yu & Yanqin Shen & Xudong Xu & Fangming Zhong, 2020. "Anlotinib for refractory advanced non-small-cell lung cancer: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-12, November.
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