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Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study

Author

Listed:
  • Margherita Torti
  • Chiara Fossati
  • Miriam Casali
  • Maria Francesca De Pandis
  • Paola Grassini
  • Fabiana Giada Radicati
  • Paola Stirpe
  • Laura Vacca
  • Ivo Iavicoli
  • Veruscka Leso
  • Marcello Ceppi
  • Marco Bruzzone
  • Stefano Bonassi
  • Fabrizio Stocchi

Abstract

Background: The aetiology of Parkinson’s disease (PD) is still very controversial, with a peculiar lack of established risk factors or protective behavior. Methods: We carried out a case–control study of 634 idiopathic PD patients admitted from 2011 to 2015 to two hospitals located in central Italy and 532 controls matched by hospital, gender and age (± 5 years). The study questionnaire included questions on host factors, family history, residence, occupation and lifestyle. Odds ratios (ORs) for PD and 95% confidence intervals (CIs) were estimated with logistic regression, adjusting for actual and potential confounders. Results: A lower OR was observed in females (0.74; 95%CI:0.58–0.96), while older age classes showed a constantly increased risk for PD (p

Suggested Citation

  • Margherita Torti & Chiara Fossati & Miriam Casali & Maria Francesca De Pandis & Paola Grassini & Fabiana Giada Radicati & Paola Stirpe & Laura Vacca & Ivo Iavicoli & Veruscka Leso & Marcello Ceppi & M, 2020. "Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-15, December.
    • Handle: RePEc:plo:pone00:0243612
    DOI: 10.1371/journal.pone.0243612
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    References listed on IDEAS

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    1. Charles B Breckenridge & Colin Berry & Ellen T Chang & Robert L Sielken Jr. & Jack S Mandel, 2016. "Association between Parkinson’s Disease and Cigarette Smoking, Rural Living, Well-Water Consumption, Farming and Pesticide Use: Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-42, April.
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    Cited by:

    1. Michael Belingheri & Yueh-Hsiu Mathilda Chiu & Stefano Renzetti & Deepika Bhasin & Chi Wen & Donatella Placidi & Manuela Oppini & Loredana Covolo & Alessandro Padovani & Roberto G. Lucchini, 2022. "Relationships of Nutritional Factors and Agrochemical Exposure with Parkinson’s Disease in the Province of Brescia, Italy," IJERPH, MDPI, vol. 19(6), pages 1-12, March.

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