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The prevalence of asymptomatic neurosyphilis among HIV-negative serofast patients in China: A meta-analysis

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  • Xutong Tan
  • Jiahui Zhang
  • Jing Li
  • Xiaoli Yue
  • Xiangdong Gong

Abstract

Introduction: Neurosyphilis can occur at any stage of syphilis. After treatment, 30%-40% of syphilis patients remained serofast. But the prevalence of asymptomatic neurosyphilis (ANS) among serofast syphilis patients remains unclear. Untimely treatment or improper management for ANS may result in neurological complications. So we perform the meta-analysis to evaluate the prevalence of ANS cases among HIV-negative serofast syphilis patients for exploring their relationship and addressing their clinical management. Methods: We searched CNKI, Wan Fang, VIP, CBMdisc, PubMed, Embase and Medline from January 1st 1990 to September 22nd 2020 for both English and Chinese records. We strictly restrict the eligibility criteria. STROBE was used for reporting quality assessment. We examined forest plots and conducted both fix-effects and random-effects to estimate prevalence by R version 3.6.2/R studio 1.2.1335 statistical software packages META version 4.9–9. If appropriate, between-study heterogeneity was examined using the I2 statistic and subgroup analysis. Results: Of 77 screened records, 5 were included. The pooled prevalence of ANS among HIV-negative serofast syphilis patients was 13% (95% CI 3%-23%; I2 = 93% P

Suggested Citation

  • Xutong Tan & Jiahui Zhang & Jing Li & Xiaoli Yue & Xiangdong Gong, 2020. "The prevalence of asymptomatic neurosyphilis among HIV-negative serofast patients in China: A meta-analysis," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-9, November.
    • Handle: RePEc:plo:pone00:0241572
    DOI: 10.1371/journal.pone.0241572
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    References listed on IDEAS

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    1. Man-Li Tong & Li-Rong Lin & Gui-Li Liu & Hui-Lin Zhang & Yan-Li Zeng & Wei-Hong Zheng & Li-Li Liu & Tian-Ci Yang, 2013. "Factors Associated with Serological Cure and the Serofast State of HIV-Negative Patients with Primary, Secondary, Latent, and Tertiary Syphilis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-7, July.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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