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Cognition and motor function: The gait and cognition pooled index

Author

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  • Jacqueline K Kueper
  • Daniel J Lizotte
  • Manuel Montero-Odasso
  • Mark Speechley
  • for the Alzheimer’s Disease Neuroimaging Initiative

Abstract

Background: There is a need for outcome measures with improved responsiveness to changes in pre-dementia populations. Both cognitive and motor function play important roles in neurodegeneration; motor function decline is detectable at early stages of cognitive decline. This proof of principle study used a Pooled Index approach to evaluate improved responsiveness of the predominant outcome measure (ADAS-Cog: Alzheimer’s Disease Assessment Scale-Cognitive Subscale) when assessment of motor function is added. Methods: Candidate Pooled Index variables were selected based on theoretical importance and pairwise correlation coefficients. Kruskal-Wallis and Mann-Whitney U tests assessed baseline discrimination. Standardized response means assessed responsiveness to longitudinal change. Results: Final selected variables for the Pooled Index include gait velocity, dual-task cost of gait velocity, and an ADAS-Cog-Proxy (statistical approximation of the ADAS-Cog using similar cognitive tests). The Pooled Index and ADAS-Cog-Proxy scores had similar ability to discriminate between pre-dementia syndromes. The Pooled Index demonstrated trends of similar or greater responsiveness to longitudinal decline than ADAS-Cog-Proxy scores. Conclusion: Adding motor function assessments to the ADAS-Cog may improve responsiveness in pre-dementia populations.

Suggested Citation

  • Jacqueline K Kueper & Daniel J Lizotte & Manuel Montero-Odasso & Mark Speechley & for the Alzheimer’s Disease Neuroimaging Initiative, 2020. "Cognition and motor function: The gait and cognition pooled index," PLOS ONE, Public Library of Science, vol. 15(9), pages 1-16, September.
    • Handle: RePEc:plo:pone00:0238690
    DOI: 10.1371/journal.pone.0238690
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    References listed on IDEAS

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    3. Olivier Beauchet & Gilles Allali & Manuel Montero-Odasso & Ervin Sejdić & Bruno Fantino & Cédric Annweiler, 2014. "Motor Phenotype of Decline in Cognitive Performance among Community-Dwellers without Dementia: Population-Based Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-10, June.
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    1. Marcelo de Maio Nascimento & Paula Andreatta Maduro & Pâmala Morais Bagano Rios & Lara dos Santos Nascimento & Carolina Nascimento Silva & Matthias Kliegel & Andreas Ihle, 2023. "The Effects of 12-Week Dual-Task Physical–Cognitive Training on Gait, Balance, Lower Extremity Muscle Strength, and Cognition in Older Adult Women: A Randomized Study," IJERPH, MDPI, vol. 20(8), pages 1-18, April.
    2. Marcelo de Maio Nascimento & Élvio Rúbio Gouveia & Adilson Marques & Bruna R. Gouveia & Priscila Marconcin & Andreas Ihle, 2022. "Gait Speed as a Biomarker of Cognitive Vulnerability: A Population-Based Study with Cognitively Normal Older Adults," Sustainability, MDPI, vol. 14(12), pages 1-12, June.

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