IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0238690.html
   My bibliography  Save this article

Cognition and motor function: The gait and cognition pooled index

Author

Listed:
  • Jacqueline K Kueper
  • Daniel J Lizotte
  • Manuel Montero-Odasso
  • Mark Speechley
  • for the Alzheimer’s Disease Neuroimaging Initiative

Abstract

Background: There is a need for outcome measures with improved responsiveness to changes in pre-dementia populations. Both cognitive and motor function play important roles in neurodegeneration; motor function decline is detectable at early stages of cognitive decline. This proof of principle study used a Pooled Index approach to evaluate improved responsiveness of the predominant outcome measure (ADAS-Cog: Alzheimer’s Disease Assessment Scale-Cognitive Subscale) when assessment of motor function is added. Methods: Candidate Pooled Index variables were selected based on theoretical importance and pairwise correlation coefficients. Kruskal-Wallis and Mann-Whitney U tests assessed baseline discrimination. Standardized response means assessed responsiveness to longitudinal change. Results: Final selected variables for the Pooled Index include gait velocity, dual-task cost of gait velocity, and an ADAS-Cog-Proxy (statistical approximation of the ADAS-Cog using similar cognitive tests). The Pooled Index and ADAS-Cog-Proxy scores had similar ability to discriminate between pre-dementia syndromes. The Pooled Index demonstrated trends of similar or greater responsiveness to longitudinal decline than ADAS-Cog-Proxy scores. Conclusion: Adding motor function assessments to the ADAS-Cog may improve responsiveness in pre-dementia populations.

Suggested Citation

  • Jacqueline K Kueper & Daniel J Lizotte & Manuel Montero-Odasso & Mark Speechley & for the Alzheimer’s Disease Neuroimaging Initiative, 2020. "Cognition and motor function: The gait and cognition pooled index," PLOS ONE, Public Library of Science, vol. 15(9), pages 1-16, September.
    • Handle: RePEc:plo:pone00:0238690
    DOI: 10.1371/journal.pone.0238690
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238690
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0238690&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0238690?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. van Buuren, Stef & Groothuis-Oudshoorn, Karin, 2011. "mice: Multivariate Imputation by Chained Equations in R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 45(i03).
    2. Friedman, Jerome H. & Hastie, Trevor & Tibshirani, Rob, 2010. "Regularization Paths for Generalized Linear Models via Coordinate Descent," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 33(i01).
    3. Olivier Beauchet & Gilles Allali & Manuel Montero-Odasso & Ervin Sejdić & Bruno Fantino & Cédric Annweiler, 2014. "Motor Phenotype of Decline in Cognitive Performance among Community-Dwellers without Dementia: Population-Based Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-10, June.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Marcelo de Maio Nascimento & Paula Andreatta Maduro & Pâmala Morais Bagano Rios & Lara dos Santos Nascimento & Carolina Nascimento Silva & Matthias Kliegel & Andreas Ihle, 2023. "The Effects of 12-Week Dual-Task Physical–Cognitive Training on Gait, Balance, Lower Extremity Muscle Strength, and Cognition in Older Adult Women: A Randomized Study," IJERPH, MDPI, vol. 20(8), pages 1-18, April.
    2. Marcelo de Maio Nascimento & Élvio Rúbio Gouveia & Adilson Marques & Bruna R. Gouveia & Priscila Marconcin & Andreas Ihle, 2022. "Gait Speed as a Biomarker of Cognitive Vulnerability: A Population-Based Study with Cognitively Normal Older Adults," Sustainability, MDPI, vol. 14(12), pages 1-12, June.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Christopher J Greenwood & George J Youssef & Primrose Letcher & Jacqui A Macdonald & Lauryn J Hagg & Ann Sanson & Jenn Mcintosh & Delyse M Hutchinson & John W Toumbourou & Matthew Fuller-Tyszkiewicz &, 2020. "A comparison of penalised regression methods for informing the selection of predictive markers," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-14, November.
    2. Ida Kubiszewski & Kenneth Mulder & Diane Jarvis & Robert Costanza, 2022. "Toward better measurement of sustainable development and wellbeing: A small number of SDG indicators reliably predict life satisfaction," Sustainable Development, John Wiley & Sons, Ltd., vol. 30(1), pages 139-148, February.
    3. Christopher Kath & Florian Ziel, 2018. "The value of forecasts: Quantifying the economic gains of accurate quarter-hourly electricity price forecasts," Papers 1811.08604, arXiv.org.
    4. Kath, Christopher & Ziel, Florian, 2021. "Conformal prediction interval estimation and applications to day-ahead and intraday power markets," International Journal of Forecasting, Elsevier, vol. 37(2), pages 777-799.
    5. Dindaroglu, Burak & Ertac, Seda, 2024. "An empirical study of sequential offer bargaining during the Festival of Sacrifice," Journal of Economic Psychology, Elsevier, vol. 101(C).
    6. Kath, Christopher & Ziel, Florian, 2018. "The value of forecasts: Quantifying the economic gains of accurate quarter-hourly electricity price forecasts," Energy Economics, Elsevier, vol. 76(C), pages 411-423.
    7. Andreas Groll & Gerhard Tutz, 2017. "Variable selection in discrete survival models including heterogeneity," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(2), pages 305-338, April.
    8. Paolo Brunori & Pedro Salas-Rojo & Paolo Verme, 2022. "Estimating Inequality with Missing Incomes," Working Papers 616, ECINEQ, Society for the Study of Economic Inequality.
    9. Claude Renaux & Laura Buzdugan & Markus Kalisch & Peter Bühlmann, 2020. "Hierarchical inference for genome-wide association studies: a view on methodology with software," Computational Statistics, Springer, vol. 35(1), pages 1-40, March.
    10. Danhyang Lee & Jae Kwang Kim, 2022. "Semiparametric imputation using conditional Gaussian mixture models under item nonresponse," Biometrics, The International Biometric Society, vol. 78(1), pages 227-237, March.
    11. Andree,Bo Pieter Johannes, 2021. "Estimating Food Price Inflation from Partial Surveys," Policy Research Working Paper Series 9886, The World Bank.
    12. Ting‐Huei Chen & Hanaa Boughal, 2021. "A penalized structural equation modeling method accounting for secondary phenotypes for variable selection on genetically regulated expression from PrediXcan for Alzheimer's disease," Biometrics, The International Biometric Society, vol. 77(1), pages 362-371, March.
    13. Halewijn M. Drent & Barbara van den Hoofdakker & Jan K. Buitelaar & Pieter J. Hoekstra & Andrea Dietrich, 2022. "Factors Related to Perceived Stigma in Parents of Children and Adolescents in Outpatient Mental Healthcare," IJERPH, MDPI, vol. 19(19), pages 1-14, October.
    14. Monica E. Ellwood-Lowe & Susan Whitfield-Gabrieli & Silvia A. Bunge, 2021. "Brain network coupling associated with cognitive performance varies as a function of a child’s environment in the ABCD study," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    15. Miriam Levi & Giulia Cereda & Francesco Cipriani & Fabio Voller & Michela Baccini, 2023. "Case-Control Study on the Routes of Transmission of SARS-CoV-2 after the Third Pandemic Wave in Tuscany, Central Italy," IJERPH, MDPI, vol. 20(3), pages 1-13, January.
    16. Elizabeth Weigensberg & Derekh Cornwell & Lindsey Leininger & Matthew Stagner & Sarah LeBarron & Jonathan Gellar & Sophie MacIntyre & Richard Chapman & Erin J. Maher & Peter J. Pecora & Kirk O’Brien, "undated". "Superutilization of Child Welfare, Medicaid, and Other Services," Mathematica Policy Research Reports caaff77fa722452aa241ace4b, Mathematica Policy Research.
    17. Helian Feng & Nicholas Mancuso & Alexander Gusev & Arunabha Majumdar & Megan Major & Bogdan Pasaniuc & Peter Kraft, 2021. "Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies," PLOS Genetics, Public Library of Science, vol. 17(4), pages 1-21, April.
    18. Phung Khanh Lam & Tran Van Ngoc & Truong Thi Thu Thuy & Nguyen Thi Hong Van & Tran Thi Nhu Thuy & Dong Thi Hoai Tam & Nguyen Minh Dung & Nguyen Thi Hanh Tien & Nguyen Tan Thanh Kieu & Cameron Simmons , 2017. "The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 11(4), pages 1-20, April.
    19. Tutz, Gerhard & Pößnecker, Wolfgang & Uhlmann, Lorenz, 2015. "Variable selection in general multinomial logit models," Computational Statistics & Data Analysis, Elsevier, vol. 82(C), pages 207-222.
    20. Noémi Kreif & Richard Grieve & Iván Díaz & David Harrison, 2015. "Evaluation of the Effect of a Continuous Treatment: A Machine Learning Approach with an Application to Treatment for Traumatic Brain Injury," Health Economics, John Wiley & Sons, Ltd., vol. 24(9), pages 1213-1228, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0238690. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.