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Inflammation, non-endothelial dependent coronary microvascular function and diastolic function—Are they linked?

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Listed:
  • Hannah E Suhrs
  • Jakob Schroder
  • Kira B Bové
  • Naja D Mygind
  • Daria Frestad
  • Marie M Michelsen
  • Theis Lange
  • Ida Gustafsson
  • Jens Kastrup
  • Eva Prescott

Abstract

Purpose: Systemic inflammation and coronary microvascular dysfunction (CMD) may be causal drivers of heart failure with preserved ejection fraction (HFpEF). We tested the hypothesis that subclinical inflammation is associated with non-endothelial dependent CMD and diastolic dysfunction. Methods: In a cross-sectional study of 336 women with angina but no flow limiting coronary artery stenosis (180 with diabetes) and 95 asymptomatic controls, blood samples were analysed for 90 biomarkers of which 34 were part of inflammatory pathways. CMD was assessed as coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography and defined as CFVR 10) (p = 0.012). Conclusion: This is the first study to link a large number of mainly inflammatory biomarkers to both CMD and E/e’, thus confirming a role of inflammation in both conditions. However, despite a high prevalence of CMD, few patients had diastolic dysfunction and the data do not support a major pathophysiologic role of non-endothelial dependent CMD in diastolic dysfunction.

Suggested Citation

  • Hannah E Suhrs & Jakob Schroder & Kira B Bové & Naja D Mygind & Daria Frestad & Marie M Michelsen & Theis Lange & Ida Gustafsson & Jens Kastrup & Eva Prescott, 2020. "Inflammation, non-endothelial dependent coronary microvascular function and diastolic function—Are they linked?," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-13, July.
    • Handle: RePEc:plo:pone00:0236035
    DOI: 10.1371/journal.pone.0236035
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    References listed on IDEAS

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    1. Gabriele G. Schiattarella & Francisco Altamirano & Dan Tong & Kristin M. French & Elisa Villalobos & Soo Young Kim & Xiang Luo & Nan Jiang & Herman I. May & Zhao V. Wang & Theodore M. Hill & Pradeep P, 2019. "Nitrosative stress drives heart failure with preserved ejection fraction," Nature, Nature, vol. 568(7752), pages 351-356, April.
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