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Influence of physical activity on serum vitamin D levels in people with multiple sclerosis

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  • Angelika Bauer
  • Ivan Lechner
  • Michael Auer
  • Thomas Berger
  • Gabriel Bsteh
  • Franziska Di Pauli
  • Harald Hegen
  • Sebastian Wurth
  • Anne Zinganell
  • Florian Deisenhammer

Abstract

In most cases, multiple sclerosis (MS) patients reduce physical activity with disease progression and many patients are found to be vitamin D deficient. The aim of this study was to explore correlations between daily physical activity in everyday life and 25-hydroxyvitamin-D3 (25(OH)D3) serum levels in mildly disabled patients with an Expanded Disability Status Scale (EDSS) ≤ 4. We analyzed serum 25(OH)D3 levels and recorded daily physical activity (activity duration, number of steps, distance, energy expenditure) using an activity tracker for 14-days in 25 women and 15 men. Participants recorded their daily sunlight exposure time by diary during the study period. We found a positive correlation between physical activity and 25(OH)D3 levels in both, Pearson correlation (r = 0.221) and multivariate regression analysis (β = 0.236), which was stronger than correlation with sunlight exposure time (β = -0.081). EDSS and physical activity were weakly correlated (r = -0.228), but no correlation between EDSS and 25(OH)D3 levels was found (r = -0.077). There were no relevant differences in physical activity (p = 0.803) and 25(OH)D3 concentrations (p = 0.385) between the EDSS groups 0 – 1.5 and 2.0 – 4.0. In conclusion, physical activity has an effect on vitamin D levels independent of sunlight exposure time in people with MS (pwMS) with low-grade disability.

Suggested Citation

  • Angelika Bauer & Ivan Lechner & Michael Auer & Thomas Berger & Gabriel Bsteh & Franziska Di Pauli & Harald Hegen & Sebastian Wurth & Anne Zinganell & Florian Deisenhammer, 2020. "Influence of physical activity on serum vitamin D levels in people with multiple sclerosis," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0234333
    DOI: 10.1371/journal.pone.0234333
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