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Associations between industry involvement and study characteristics at the time of trial registration in biomedical research

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  • Anna Lene Seidler
  • Kylie E Hunter
  • Nicholas Chartres
  • Lisa M Askie

Abstract

Background: Commercial or industry funding is associated with outcomes that favour the study funder in published studies, across various areas of research. However, it is currently unclear whether there are differences between trials with and without industry involvement at the stage of trial registration. Objective: To determine whether industry involvement (industry sponsorship, funding, or collaboration) is associated with trial characteristics at the time of trial registration. Methods: We conducted a cross-sectional analysis of all interventional studies registered on the Australian New Zealand Clinical Trials Registry in 2017 and classified them by industry involvement. We analysed whether there were differences in study characteristics (including type of control, sample size, study phase, randomisation, registration timing, and purpose of study) by industry involvement. Results: Industry involvement was reported by 21% of the 1,433 included trials. Only 40% of trials with industry involvement used an active control compared to 58% of non-industry trials (OR = 0.49, 95%CI = 0.38 to 0.63, p

Suggested Citation

  • Anna Lene Seidler & Kylie E Hunter & Nicholas Chartres & Lisa M Askie, 2019. "Associations between industry involvement and study characteristics at the time of trial registration in biomedical research," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0222117
    DOI: 10.1371/journal.pone.0222117
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    2. Lisa Bero & Fieke Oostvogel & Peter Bacchetti & Kirby Lee, 2007. "Factors Associated with Findings of Published Trials of Drug–Drug Comparisons: Why Some Statins Appear More Efficacious than Others," PLOS Medicine, Public Library of Science, vol. 4(6), pages 1-10, June.
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