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When Are Statins Cost-Effective in Cardiovascular Prevention? A Systematic Review of Sponsorship Bias and Conclusions in Economic Evaluations of Statins

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  • Ferrán Catalá-López
  • Gabriel Sanfélix-Gimeno
  • Manuel Ridao
  • Salvador Peiró

Abstract

Background: We examined sponsorship of published cost-effectiveness analyses of statin use for cardiovascular (CV) prevention, and determined whether the funding source is associated with study conclusions. Methods and Findings: We searched PubMed/MEDLINE (up to June 2011) to identify cost-effectiveness analyses of statin use for CV prevention reporting outcomes as incremental costs per quality-adjusted life years (QALY) and/or life years gained (LYG). We examined relationships between the funding source and the study conclusions by means of tests of differences between proportions. Seventy-five studies were included. Forty-eight studies (64.0%) were industry-sponsored. Fifty-two (69.3%) articles compared statins versus non-active alternatives. Secondary CV prevention represented 42.7% of articles, followed by primary CV prevention (38.7%) and both (18.7%). Overall, industry-sponsored studies were much less likely to report unfavourable or neutral conclusions (0% versus 37.1%; p

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  • Ferrán Catalá-López & Gabriel Sanfélix-Gimeno & Manuel Ridao & Salvador Peiró, 2013. "When Are Statins Cost-Effective in Cardiovascular Prevention? A Systematic Review of Sponsorship Bias and Conclusions in Economic Evaluations of Statins," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-1, July.
    • Handle: RePEc:plo:pone00:0069462
    DOI: 10.1371/journal.pone.0069462
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    References listed on IDEAS

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    Cited by:

    1. Arnaud Vaganay, 2016. "Outcome Reporting Bias in Government-Sponsored Policy Evaluations: A Qualitative Content Analysis of 13 Studies," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-21, September.
    2. Joke Bilcke & Frederik Verelst & Philippe Beutels, 2018. "Sponsorship Bias in Base-Case Values and Uncertainty Bounds of Health Economic Evaluations? A Systematic Review of Herpes Zoster Vaccination," Medical Decision Making, , vol. 38(6), pages 730-745, August.

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