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Lifetime benefits of early detection and treatment of diabetic kidney disease

Author

Listed:
  • Julia Thornton Snider
  • Jeffrey Sullivan
  • Emma van Eijndhoven
  • Michael K Hansen
  • Nobel Bellosillo
  • Cheryl Neslusan
  • Ellen O’Brien
  • Ralph Riley
  • Seth Seabury
  • Bertram L Kasiske

Abstract

Objectives: Diabetic kidney disease (DKD) is a frequent complication of diabetes with potentially devastating consequences that may be prevented or delayed. This study aimed to estimate the health and economic benefit of earlier diagnosis and treatment of DKD. Methods: Life expectancy and medical spending for people with diabetes were modeled using The Health Economics Medical Innovation Simulation (THEMIS). THEMIS uses data from the Health and Retirement Study to model cohorts of individuals over age 50 to project population-level lifetime health and economic outcomes. DKD status was imputed based on diagnoses and laboratory values in the National Health and Nutrition Examination Survey. We simulated the implementation of a new biomarker identifying people with diabetes at an elevated risk of DKD and DKD patients at risk of rapid progression. Results: Compared to baseline, the prevalence of DKD declined 5.1% with a novel prognostic biomarker test, while the prevalence of diabetes with stage 5 chronic kidney disease declined 3.0%. Consequently, people with diabetes gained 0.2 years in life expectancy, while per-capita annual medical spending fell by 0.3%. The estimated cost was $12,796 per life-year gained and $25,842 per quality-adjusted life-year. Conclusions: A biomarker test that allows earlier treatment reduces DKD prevalence and slows DKD progression, thereby increasing life expectancy among people with diabetes while raising healthcare spending by less than one percent.

Suggested Citation

  • Julia Thornton Snider & Jeffrey Sullivan & Emma van Eijndhoven & Michael K Hansen & Nobel Bellosillo & Cheryl Neslusan & Ellen O’Brien & Ralph Riley & Seth Seabury & Bertram L Kasiske, 2019. "Lifetime benefits of early detection and treatment of diabetic kidney disease," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0217487
    DOI: 10.1371/journal.pone.0217487
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    Cited by:

    1. Ruth Usó-Talamantes & Silvia González-de-Julián & Javier Díaz-Carnicero & Inmaculada Saurí-Ferrer & José Luis Trillo-Mata & Marc Carrasco-Pérez & Jorge Navarro-Pérez & José Luis Górriz & David Vivas-C, 2021. "Cost of Type 2 Diabetes Patients with Chronic Kidney Disease Based on Real-World Data: An Observational Population-Based Study in Spain," IJERPH, MDPI, vol. 18(18), pages 1-14, September.
    2. Jou-Yin Chen & Shiqi Deng & Yukiko Wagatsuma, 2023. "Combination of Risks of BMI and Health-Related Lifestyles on Kidney Function in the Prediabetic Japanese Population: A Prospective Cohort Study," IJERPH, MDPI, vol. 20(7), pages 1-10, March.

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