IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0216937.html
   My bibliography  Save this article

The prevalence and impact of psychiatric symptoms in an undiagnosed diseases clinical program

Author

Listed:
  • Gabriella Waserstein
  • Clyde Partin
  • Debra Cohen
  • Pamela Schettler
  • Becky Kinkead
  • Mark Hyman Rapaport

Abstract

In 2008, the NIH launched an undiagnosed diseases program to investigate difficult to diagnose, and typically, multi-system diseases. The objective of this study was to evaluate the presence of psychiatric symptoms or psychiatric diagnoses in a cohort of patients seeking care at the Emory Special Diagnostic Service clinic. We hypothesized that psychiatric symptoms would be prevalent and associated with trauma exposure, and a decreased quality of life and functioning. This is a cross-sectional, retrospective analysis of 247 patients seen between February 7, 2014 and May 31, 2017. The sources for data included the Emory Health History Questionnaire (HHQ) that had the work and social adjustment and quality of life enjoyment and satisfaction questionnaire–short form (QLSQ) embedded in it; medical records, and the comprehensive standardized special diagnostic clinic forms. Primary outcomes were presence of any psychiatric symptom, based on report of the symptom on the HHQ or medical record, or presence of a confirmed preexisting psychiatric disorder. Seventy-two percent of patients had at least one psychiatric symptom while 24.3% of patients had a pre-existing psychiatric diagnosis. Patients with any psychiatric symptom had significantly diminished Q-LES-Q scores (45.27 ± 18.63) versus patients with no psychiatric symptoms (62.01 ± 21.57, t = 5.60, df = 225, p

Suggested Citation

  • Gabriella Waserstein & Clyde Partin & Debra Cohen & Pamela Schettler & Becky Kinkead & Mark Hyman Rapaport, 2019. "The prevalence and impact of psychiatric symptoms in an undiagnosed diseases clinical program," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-13, June.
    • Handle: RePEc:plo:pone00:0216937
    DOI: 10.1371/journal.pone.0216937
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216937
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0216937&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0216937?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Nettleton, Sarah, 2006. "'I just want permission to be ill': Towards a sociology of medically unexplained symptoms," Social Science & Medicine, Elsevier, vol. 62(5), pages 1167-1178, March.
    2. Colin D Mathers & Dejan Loncar, 2006. "Projections of Global Mortality and Burden of Disease from 2002 to 2030," PLOS Medicine, Public Library of Science, vol. 3(11), pages 1-20, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jia Lu & Shabana Jamani & Joseph Benjamen & Eric Agbata & Olivia Magwood & Kevin Pottie, 2020. "Global Mental Health and Services for Migrants in Primary Care Settings in High-Income Countries: A Scoping Review," IJERPH, MDPI, vol. 17(22), pages 1-28, November.
    2. Eldon Spackman & Stewart Richmond & Mark Sculpher & Martin Bland & Stephen Brealey & Rhian Gabe & Ann Hopton & Ada Keding & Harriet Lansdown & Sara Perren & David Torgerson & Ian Watt & Hugh MacPherso, 2014. "Cost-Effectiveness Analysis of Acupuncture, Counselling and Usual Care in Treating Patients with Depression: The Results of the ACUDep Trial," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-12, November.
    3. Peele, Morgan & Wolf, Sharon, 2020. "Predictors of anxiety and depressive symptoms among teachers in Ghana: Evidence from a randomized controlled trial," Social Science & Medicine, Elsevier, vol. 253(C).
    4. Carsten Hinrichsen & Vibeke Jenny Koushede & Katrine Rich Madsen & Line Nielsen & Nanna Gram Ahlmark & Ziggi Ivan Santini & Charlotte Meilstrup, 2020. "Implementing Mental Health Promotion Initiatives—Process Evaluation of the ABCs of Mental Health in Denmark," IJERPH, MDPI, vol. 17(16), pages 1-26, August.
    5. Emmanuel Peprah & Elisabet Caler & Anya Snyder & Fassil Ketema, 2020. "Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV," IJERPH, MDPI, vol. 17(13), pages 1-7, June.
    6. Stockl, Andrea, 2007. "Complex syndromes, ambivalent diagnosis, and existential uncertainty: The case of Systemic Lupus Erythematosus (SLE)," Social Science & Medicine, Elsevier, vol. 65(7), pages 1549-1559, October.
    7. Hoehun Ha & Wei Tu, 2018. "An Ecological Study on the Spatially Varying Relationship between County-Level Suicide Rates and Altitude in the United States," IJERPH, MDPI, vol. 15(4), pages 1-16, April.
    8. Trundle, Catherine, 2011. "Biopolitical endpoints: Diagnosing a deserving British nuclear test veteran," Social Science & Medicine, Elsevier, vol. 73(6), pages 882-888, September.
    9. Eduardo Martínez-Martínez & María Luisa Zaragoza & Elmer Solano & Brenda Figueroa & Patricia Zúñiga & Juan P Laclette, 2012. "Health Research Funding in Mexico: The Need for a Long-Term Agenda," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-11, December.
    10. G. Guindon, 2014. "The impact of tobacco prices on smoking onset in Vietnam: duration analyses of retrospective data," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 15(1), pages 19-39, January.
    11. Jessica Pinaire & Jérôme Azé & Sandra Bringay & Guillaume Cayla & Paul Landais, 2019. "Hospital burden of coronary artery disease: Trends of myocardial infarction and/or percutaneous coronary interventions in France 2009–2014," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-21, May.
    12. Nuño, Roberto & Coleman, Katie & Bengoa, Rafael & Sauto, Regina, 2012. "Integrated care for chronic conditions: The contribution of the ICCC Framework," Health Policy, Elsevier, vol. 105(1), pages 55-64.
    13. Hsiu-Ju Chang & Chien-Chang Liao & Chaur-Jong Hu & Winston W Shen & Ta-Liang Chen, 2013. "Psychiatric Disorders after Epilepsy Diagnosis: A Population-Based Retrospective Cohort Study," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.
    14. Hui-Hsin Ko & Wu-Chien Chien & Yen-Hung Lin & Chi-Hsiang Chung & Shih-Jung Cheng, 2017. "Examining the correlation between diabetes and odontogenic infection: A nationwide, retrospective, matched-cohort study in Taiwan," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-13, June.
    15. D. K. Shangodoyin & A. O. Adebile & J. F. Ojo & J. O. Olaomi, 2012. "Time series model for predicting the mean death rate of a disease," Statistics in Transition new series, Główny Urząd Statystyczny (Polska), vol. 13(2), pages 405-418, June.
    16. Moyer, Jonathan D. & Hedden, Steve, 2020. "Are we on the right path to achieve the sustainable development goals?," World Development, Elsevier, vol. 127(C).
    17. Rhodes, Tim & Bernays, Sarah & Terzic, Katarina Jankovic, 2009. "Medical promise and the recalibration of expectation: Hope and HIV treatment engagement in a transitional setting," Social Science & Medicine, Elsevier, vol. 68(6), pages 1050-1059, March.
    18. Lagravinese, R. & Moscone, F. & Tosetti, E. & Lee, H., 2014. "The impact of air pollution on hospital admissions: Evidence from Italy," Regional Science and Urban Economics, Elsevier, vol. 49(C), pages 278-285.
    19. Ahmad Salman & Maha Sellami & Abdulla Saeed AL-Mohannadi & Sungsoo Chun, 2019. "The Associations between Mental Well-Being and Adherence to Physical Activity Guidelines in Patients with Cardiovascular Disease: Results from the Scottish Health Survey," IJERPH, MDPI, vol. 16(19), pages 1-13, September.
    20. Kuan-Yin Lin & Chi-Chuan Wang & Chia-Hui Lin & Wang-Huei Sheng & Shan-Chwen Chang, 2015. "Fluoroquinolones versus β-Lactam/β-Lactamase Inhibitors in Outpatients with Chronic Obstructive Pulmonary Disease and Pneumonia: A Nationwide Population-Based Study," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-12, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0216937. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.