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Risk factors of neonatal sepsis in India: A systematic review and meta-analysis

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  • Shruti Murthy
  • Myron Anthony Godinho
  • Vasudeva Guddattu
  • Leslie Edward Simon Lewis
  • N Sreekumaran Nair

Abstract

Background: The incidence of neonatal sepsis in India is the highest in the world. Evidence regarding its risk factors can guide clinical practice and prevention strategies. Objective: To review, assess and synthesize the available literature from India on the risk factors of sepsis among neonates. Methodology: A systematic review was conducted. We searched PubMed, CINAHL, Scopus, Web of Science, Popline, IndMed, Indian Science Abstracts and Google Scholar from inception up to March 23, 2018 to identify observational analytical studies reporting on risk factors of laboratory-confirmed neonatal sepsis in India. Two authors independently screened studies (title, abstract and full-text stages), extracted data, and assessed quality. A random-effects meta-analysis was performed as substantial heterogeneity was anticipated. Subgroup and sensitivity analyses were additionally performed. Effect size in our review included odds ratio and standardized mean difference. Results: Fifteen studies were included from 11,009 records, of which nine were prospective in design. Birthweight and gestational age at delivery were the most frequently reported factors. On meta-analyses, it was found that male sex (OR: 1.3, 95% CI: 1.02, 1.68), out born neonates (OR: 5.5, 95% CI: 2.39, 12.49), need for artificial ventilation (OR: 5.61; 95% CI: 8.21, 41.18), gestational age

Suggested Citation

  • Shruti Murthy & Myron Anthony Godinho & Vasudeva Guddattu & Leslie Edward Simon Lewis & N Sreekumaran Nair, 2019. "Risk factors of neonatal sepsis in India: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-26, April.
    • Handle: RePEc:plo:pone00:0215683
    DOI: 10.1371/journal.pone.0215683
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    1. Biruk Beletew Abate & Ayelign Mengesha Kasie & Melese Abate Reta & Mesfin Wudu Kassaw, 2020. "Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 65(9), pages 1623-1633, December.

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