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The importance of forgetting: Limiting memory improves recovery of topological characteristics from neural data

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  • Samir Chowdhury
  • Bowen Dai
  • Facundo Mémoli

Abstract

We develop of a line of work initiated by Curto and Itskov towards understanding the amount of information contained in the spike trains of hippocampal place cells via topology considerations. Previously, it was established that simply knowing which groups of place cells fire together in an animal’s hippocampus is sufficient to extract the global topology of the animal’s physical environment. We model a system where collections of place cells group and ungroup according to short-term plasticity rules. In particular, we obtain the surprising result that in experiments with spurious firing, the accuracy of the extracted topological information decreases with the persistence (beyond a certain regime) of the cell groups. This suggests that synaptic transience, or forgetting, is a mechanism by which the brain counteracts the effects of spurious place cell activity.

Suggested Citation

  • Samir Chowdhury & Bowen Dai & Facundo Mémoli, 2018. "The importance of forgetting: Limiting memory improves recovery of topological characteristics from neural data," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-20, September.
    • Handle: RePEc:plo:pone00:0202561
    DOI: 10.1371/journal.pone.0202561
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    References listed on IDEAS

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    1. Y Dabaghian & F Mémoli & L Frank & G Carlsson, 2012. "A Topological Paradigm for Hippocampal Spatial Map Formation Using Persistent Homology," PLOS Computational Biology, Public Library of Science, vol. 8(8), pages 1-14, August.
    2. Carina Curto & Vladimir Itskov, 2008. "Cell Groups Reveal Structure of Stimulus Space," PLOS Computational Biology, Public Library of Science, vol. 4(10), pages 1-13, October.
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