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Multivariate analysis of genomics data to identify potential pleiotropic genes for type 2 diabetes, obesity and dyslipidemia using Meta-CCA and gene-based approach

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  • Yuan-Cheng Chen
  • Chao Xu
  • Ji-Gang Zhang
  • Chun-Ping Zeng
  • Xia-Fang Wang
  • Rou Zhou
  • Xu Lin
  • Zeng-Xin Ao
  • Jun-Min Lu
  • Jie Shen
  • Hong-Wen Deng

Abstract

Previous studies have demonstrated the genetic correlations between type 2 diabetes, obesity and dyslipidemia, and indicated that many genes have pleiotropic effects on them. However, these pleiotropic genes have not been well-defined. It is essential to identify pleiotropic genes using systematic approaches because systematically analyzing correlated traits is an effective way to enhance their statistical power. To identify potential pleiotropic genes for these three disorders, we performed a systematic analysis by incorporating GWAS (genome-wide associated study) datasets of six correlated traits related to type 2 diabetes, obesity and dyslipidemia using Meta-CCA (meta-analysis using canonical correlation analysis). Meta-CCA is an emerging method to systematically identify potential pleiotropic genes using GWAS summary statistics of multiple correlated traits. 2,720 genes were identified as significant genes after multiple testing (Bonferroni corrected p value

Suggested Citation

  • Yuan-Cheng Chen & Chao Xu & Ji-Gang Zhang & Chun-Ping Zeng & Xia-Fang Wang & Rou Zhou & Xu Lin & Zeng-Xin Ao & Jun-Min Lu & Jie Shen & Hong-Wen Deng, 2018. "Multivariate analysis of genomics data to identify potential pleiotropic genes for type 2 diabetes, obesity and dyslipidemia using Meta-CCA and gene-based approach," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-16, August.
    • Handle: RePEc:plo:pone00:0201173
    DOI: 10.1371/journal.pone.0201173
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    References listed on IDEAS

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    1. Yan-Wei Yin & Qian-Qian Sun & Pei-Jian Wang & Li Qiao & Ai-Min Hu & Hong-Li Liu & Qi Wang & Zhi-Zhen Hou, 2014. "Genetic Polymorphism of Apolipoprotein A5 Gene and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis of 15,137 Subjects," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    2. Shashaank Vattikuti & Juen Guo & Carson C Chow, 2012. "Heritability and Genetic Correlations Explained by Common SNPs for Metabolic Syndrome Traits," PLOS Genetics, Public Library of Science, vol. 8(3), pages 1-8, March.
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