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Genetic Polymorphism of Apolipoprotein A5 Gene and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis of 15,137 Subjects

Author

Listed:
  • Yan-Wei Yin
  • Qian-Qian Sun
  • Pei-Jian Wang
  • Li Qiao
  • Ai-Min Hu
  • Hong-Li Liu
  • Qi Wang
  • Zhi-Zhen Hou

Abstract

Background: Several studies have investigated whether the polymorphism in the apolipoprotein A5 (APOA5) is associated with type 2 diabetes mellitus (T2DM) risk. However, those studies have produced inconsistent results. The purpose of this study was to investigate whether the APOA5 -1131T/C polymorphism (rs662799) confers significant susceptibility to T2DM using a meta-analysis. Methods: PubMed, Embase, Web of Science, Cochrane database, CBMdisc, CNKI and Google Scholar were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0. Results: A total of 19 studies included 4,767 T2DM cases and 10,370 controls (four studies involving 555 T2DM cases and 2958 controls were performed among Europeans and 15 studies involving 4212 T2DM cases and 7412 controls were performed among Asians) were combined showing significant association between the APOA5 -1131T/C polymorphism and T2DM risk (for C allele vs. T allele: OR = 1.28, 95% CI = 1.17–1.40, p

Suggested Citation

  • Yan-Wei Yin & Qian-Qian Sun & Pei-Jian Wang & Li Qiao & Ai-Min Hu & Hong-Li Liu & Qi Wang & Zhi-Zhen Hou, 2014. "Genetic Polymorphism of Apolipoprotein A5 Gene and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis of 15,137 Subjects," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    • Handle: RePEc:plo:pone00:0089167
    DOI: 10.1371/journal.pone.0089167
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    Cited by:

    1. Yuan-Cheng Chen & Chao Xu & Ji-Gang Zhang & Chun-Ping Zeng & Xia-Fang Wang & Rou Zhou & Xu Lin & Zeng-Xin Ao & Jun-Min Lu & Jie Shen & Hong-Wen Deng, 2018. "Multivariate analysis of genomics data to identify potential pleiotropic genes for type 2 diabetes, obesity and dyslipidemia using Meta-CCA and gene-based approach," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-16, August.

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