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Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis

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  • Elmira Agah
  • Arshia Zardoui
  • Amene Saghazadeh
  • Mona Ahmadi
  • Abbas Tafakhori
  • Nima Rezaei

Abstract

Identifying a reliable biomarker may accelerate diagnosis of multiple sclerosis (MS) and lead to early management of the disease. Accumulating evidence suggest that cerebrospinal fluid (CSF) and peripheral blood concentration of osteopontin (OPN) may have diagnostic and prognostic value in MS. We conducted a systematic review and meta-analysis of studies that measured peripheral blood and CSF levels of OPN in MS patients and controls to evaluate the diagnostic potential of this biomarker better. We searched PubMed, Web of Science and Scopus databases to find articles that measured OPN concentration in peripheral blood and CSF samples from MS patients up to October 19, 2016. Q statistic tests and the I2 index were applied for heterogeneity assessment. If the I2 index was less than 40%, the fixed-effects model was used for meta-analysis. Random-effects meta-analysis was chosen if the I2 value was greater than 40%. After removal of duplicates, 918 articles were identified, and 27 of them fulfilled the inclusion criteria. We included 22 eligible studies in the final meta-analysis. MS patients, in general, had considerably higher levels of OPN in their CSF and blood when compared to all types of controls (p

Suggested Citation

  • Elmira Agah & Arshia Zardoui & Amene Saghazadeh & Mona Ahmadi & Abbas Tafakhori & Nima Rezaei, 2018. "Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-18, January.
    • Handle: RePEc:plo:pone00:0190252
    DOI: 10.1371/journal.pone.0190252
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    1. Mohsen Khademi & Ann M Dring & Jonathan D Gilthorpe & Anna Wuolikainen & Faiez Al Nimer & Robert A Harris & Magnus Andersson & Lou Brundin & Fredrik Piehl & Tomas Olsson & Anders Svenningsson, 2013. "Intense Inflammation and Nerve Damage in Early Multiple Sclerosis Subsides at Older Age: A Reflection by Cerebrospinal Fluid Biomarkers," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-12, May.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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