IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0179047.html
   My bibliography  Save this article

Regulation of neural stem cell proliferation and differentiation by Kinesin family member 2a

Author

Listed:
  • Dong Sun
  • Xue Zhou
  • Hua-Li Yu
  • Xiao-Xiao He
  • Wei-Xiang Guo
  • Wen-Cheng Xiong
  • Xiao-Juan Zhu

Abstract

In the developing neocortex, cells in the ventricular/subventricular zone are largely multipotent neural stem cells and neural progenitor cells. These cells undergo self-renewal at the early stage of embryonic development to amplify the progenitor pool and subsequently differentiate into neurons. It is thus of considerable interest to investigate mechanisms controlling the switch from neural stem cells or neural progenitor cells to neurons. Here, we present evidence that Kif2a, a member of the Kinesin-13 family, plays a role in regulating the proliferation and differentiation of neural stem cells or neural progenitor cells at embryonic day 13.5. Silencing Kif2a by use of in utero electroporation of Kif2a shRNA reduced neural stem cells proliferation or self-renewal but increased neuronal differentiation. We further found that knockdown of Kif2a decreased the protein level of β-catenin, which is a critical molecule for neocortical neurogenesis. Together, these results reveal an important function of Kif2a in embryonic neocortical neurogenesis.

Suggested Citation

  • Dong Sun & Xue Zhou & Hua-Li Yu & Xiao-Xiao He & Wei-Xiang Guo & Wen-Cheng Xiong & Xiao-Juan Zhu, 2017. "Regulation of neural stem cell proliferation and differentiation by Kinesin family member 2a," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-17, June.
    • Handle: RePEc:plo:pone00:0179047
    DOI: 10.1371/journal.pone.0179047
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179047
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0179047&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0179047?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Huali Yu & Nannan Wang & Xingda Ju & Yan Yang & Dong Sun & Mingming Lai & Lei Cui & Muhammad Abid Sheikh & Jianhua Zhang & Xingzhi Wang & Xiaojuan Zhu, 2012. "PtdIns (3,4,5) P3 Recruitment of Myo10 Is Essential for Axon Development," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-11, May.
    2. Joe Howard & Anthony A. Hyman, 2003. "Dynamics and mechanics of the microtubule plus end," Nature, Nature, vol. 422(6933), pages 753-758, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ishutesh Jain & Mandar M Inamdar & Ranjith Padinhateeri, 2015. "Statistical Mechanics Provides Novel Insights into Microtubule Stability and Mechanism of Shrinkage," PLOS Computational Biology, Public Library of Science, vol. 11(2), pages 1-23, February.
    2. Chunting Zhang & Changmiao Guo & Ryan W. Russell & Caitlin M. Quinn & Mingyue Li & John C. Williams & Angela M. Gronenborn & Tatyana Polenova, 2022. "Magic-angle-spinning NMR structure of the kinesin-1 motor domain assembled with microtubules reveals the elusive neck linker orientation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Yutaka Takeda & Takumi Chinen & Shunnosuke Honda & Sho Takatori & Shotaro Okuda & Shohei Yamamoto & Masamitsu Fukuyama & Koh Takeuchi & Taisuke Tomita & Shoji Hata & Daiju Kitagawa, 2024. "Molecular basis promoting centriole triplet microtubule assembly," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Raptis, Theophanes E., 2017. "“Viral” Turing Machines, computation from noise and combinatorial hierarchies," Chaos, Solitons & Fractals, Elsevier, vol. 104(C), pages 734-740.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0179047. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.