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Impact of systemic inflammation on gastric cancer outcomes

Author

Listed:
  • Xuechao Liu
  • Shangxiang Chen
  • Jianjun Liu
  • Dazhi Xu
  • Wei Li
  • Youqing Zhan
  • Yuanfang Li
  • Yingbo Chen
  • Zhiwei Zhou
  • Xiaowei Sun

Abstract

Background: The prognostic value of neutrophil-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS) has been extensively validated in various cancers. We aimed to examine the usefulness of a combination of NLR and GPS (named CNG) for predicting survival outcomes in patients after curative resection for gastric cancer (GC). Methods: We retrospectively analyzed the records of 1056 patients who underwent curative resection as initial treatment for GC from October 2000 to September 2012. The preoperative CNG was calculated as follows: patients with hypoalbuminemia ( 10 mg/L), and elevated NLR (≥ 2) were allocated a score of 3; patients with two, one, or no abnormal values were allocated a score of 2, 1, or 0, respectively. Results: The NLR and GPS were the only inflammatory variables independently associated with overall survival (OS) in multivariate analysis. When they were replaced by CNG in multivariate analysis, CNG was independently associated with OS (hazard ratio [HR] for CNG 1 [1.367, 95% CI: 1.065–1.755; P = 0.014], CNG 2 [1.887, 95% CI: 1.182–3.011; P = 0.008], and CNG 3 [2.224, 95% CI: 1.238–3.997; P = 0.008]; P = 0.020). In stage-matched analysis, the prognostic significance was still maintained in stage I-III (P = 0.002, P = 0.042, and P

Suggested Citation

  • Xuechao Liu & Shangxiang Chen & Jianjun Liu & Dazhi Xu & Wei Li & Youqing Zhan & Yuanfang Li & Yingbo Chen & Zhiwei Zhou & Xiaowei Sun, 2017. "Impact of systemic inflammation on gastric cancer outcomes," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0174085
    DOI: 10.1371/journal.pone.0174085
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    References listed on IDEAS

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    1. Lisa M. Coussens & Zena Werb, 2002. "Inflammation and cancer," Nature, Nature, vol. 420(6917), pages 860-867, December.
    2. Xi Zhang & Wei Zhang & Li-jin Feng, 2014. "Prognostic Significance of Neutrophil Lymphocyte Ratio in Patients with Gastric Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-7, November.
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    Cited by:

    1. Mi-Rae Kim & A-Sol Kim & Hye-In Choi & Jae-Hun Jung & Ji Yeon Park & Hae-Jin Ko, 2020. "Inflammatory markers for predicting overall survival in gastric cancer patients: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-17, July.

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