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Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy

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  • Stuart K Kim
  • Thomas R Roos
  • Andrew K Roos
  • John P Kleimeyer
  • Marwa A Ahmed
  • Gabrielle T Goodlin
  • Michael Fredericson
  • John P A Ioannidis
  • Andrew L Avins
  • Jason L Dragoo

Abstract

Achilles tendinopathy or rupture and anterior cruciate ligament (ACL) rupture are substantial injuries affecting athletes, associated with delayed recovery or inability to return to competition. To identify genetic markers that might be used to predict risk for these injuries, we performed genome-wide association screens for these injuries using data from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort consisting of 102,979 individuals. We did not find any single nucleotide polymorphisms (SNPs) associated with either of these injuries with a p-value that was genome-wide significant (p

Suggested Citation

  • Stuart K Kim & Thomas R Roos & Andrew K Roos & John P Kleimeyer & Marwa A Ahmed & Gabrielle T Goodlin & Michael Fredericson & John P A Ioannidis & Andrew L Avins & Jason L Dragoo, 2017. "Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-16, March.
    • Handle: RePEc:plo:pone00:0170422
    DOI: 10.1371/journal.pone.0170422
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    References listed on IDEAS

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    1. Eric Jorgenson & Nadja Makki & Ling Shen & David C. Chen & Chao Tian & Walter L. Eckalbar & David Hinds & Nadav Ahituv & Andrew Avins, 2015. "A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
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    Cited by:

    1. Valeria Perugini & Valeria Perugini & Valeria Perugini & Valeria Perugini, 2018. "Considering Genetics in Tendinopathy Management," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 10(4), pages 7922-7924, October.

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