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Metabolic syndrome and its components among rheumatoid arthritis patients: A comprehensive updated systematic review and meta-analysis

Author

Listed:
  • Jamal Hallajzadeh
  • Saeid Safiri
  • Mohammad Ali Mansournia
  • Maliheh Khoramdad
  • Neda Izadi
  • Amir Almasi-Hashiani
  • Reza Pakzad
  • Erfan Ayubi
  • Mark J M Sullman
  • Nahid Karamzad

Abstract

Background: Estimating the current global prevalence of metabolic syndrome (MetS), and its components, among rheumatoid arthritis (RA) patients is necessary in order to formulate preventative strategies and to ensure there are adequate community resources available for these patients. Furthermore, the association between RA and MetS is controversial and has not previously been comprehensively assessed. Therefore, the present study aimed to: 1) determine the prevalence of MetS, and its components, among RA patients across the world 2) update the odds ratio of MetS in RA patients, compared to healthy controls, using a comprehensive systematic review and meta-analysis. Methods: International databases, including: the Web of Science, PubMed, Scopus, Embase, CINAHL and other relevant databases were searched to identify English language articles which reported the prevalence and risk of MetS in RA patients between January 2000 and August 2016. The meta-analysis only included studies which clearly described the time and location of the study, utilised adequate sampling strategies, and appropriate statistical analyses. Results: The meta-analyses of prevalence (70 studies [n = 12612]) and risk (43 studies [n = 35220]) of MetS in RA patients were undertaken separately. The overall pooled prevalence of MetS was 30.65% (95% CI: 27.87–33.43), but this varied from 14.32% (95% CI: 10.59–18.05) to 37.83% (95% CI: 31.05–44.61), based upon the diagnostic criteria used. The prevalence of MetS also varied slightly between males (31.94%, 95% CI: 24.37–39.51) and females (33.03%, 95% CI: 28.09–37.97), but this was not statistically significant. The overall pooled odds ratio (OR) of MetS in RA patients, compared to healthy controls, was 1.44 (95% CI: 1.20–1.74), but this ranged from 0.70 (95% CI: 0.27–1.76) to 4.09 (95% CI: 2.03–8.25), depending on the criteria used. The mean age and diagnostic criteria of MetS were identified as sources of heterogeneity in the estimated odds ratios between studies (P

Suggested Citation

  • Jamal Hallajzadeh & Saeid Safiri & Mohammad Ali Mansournia & Maliheh Khoramdad & Neda Izadi & Amir Almasi-Hashiani & Reza Pakzad & Erfan Ayubi & Mark J M Sullman & Nahid Karamzad, 2017. "Metabolic syndrome and its components among rheumatoid arthritis patients: A comprehensive updated systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-21, March.
    • Handle: RePEc:plo:pone00:0170361
    DOI: 10.1371/journal.pone.0170361
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    References listed on IDEAS

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    1. Jonathan A.C. Sterne & Roger M. Harbord, 2004. "Funnel plots in meta-analysis," Stata Journal, StataCorp LP, vol. 4(2), pages 127-141, June.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    3. Jianming Zhang & Lingyu Fu & Jingpu Shi & Xin Chen & Yongze Li & Bing Ma & Yao Zhang, 2013. "The Risk of Metabolic Syndrome in Patients with Rheumatoid Arthritis: A Meta-Analysis of Observational Studies," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
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