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A Systematic Review of Cost-Effectiveness Studies Reporting Cost-per-DALY Averted

Author

Listed:
  • Peter J Neumann
  • Teja Thorat
  • Yue Zhong
  • Jordan Anderson
  • Megan Farquhar
  • Mark Salem
  • Eileen Sandberg
  • Cayla J Saret
  • Colby Wilkinson
  • Joshua T Cohen

Abstract

Introduction: Calculating the cost per disability-adjusted life years (DALYs) averted associated with interventions is an increasing popular means of assessing the cost-effectiveness of strategies to improve population health. However, there has been no systematic attempt to characterize the literature and its evolution. Methods: We conducted a systematic review of cost-effectiveness studies reporting cost-per-DALY averted from 2000 through 2015. We developed the Global Health Cost-Effectiveness Analysis (GHCEA) Registry, a repository of English-language cost-per-DALY averted studies indexed in PubMed. To identify candidate studies, we searched PubMed for articles with titles or abstracts containing the phrases “disability-adjusted” or “DALY”. Two reviewers with training in health economics independently reviewed each article selected in our abstract review, gathering information using a standardized data collection form. We summarized descriptive characteristics on study methodology: e.g., intervention type, country of study, study funder, study perspective, along with methodological and reporting practices over two time periods: 2000–2009 and 2010–2015. We analyzed the types of costs included in analyses, the study quality on a scale from 1 (low) to 7 (high), and examined the correlation between diseases researched and the burden of disease in different world regions. Results: We identified 479 cost-per-DALY averted studies published from 2000 through 2015. Studies from Sub-Saharan Africa comprised the largest portion of published studies. The disease areas most commonly studied were communicable, maternal, neonatal, and nutritional disorders (67%), followed by non-communicable diseases (28%). A high proportion of studies evaluated primary prevention strategies (59%). Pharmaceutical interventions were commonly assessed (32%) followed by immunizations (28%). Adherence to good practices for conducting and reporting cost-effectiveness analysis varied considerably. Studies mainly included formal healthcare sector costs. A large number of the studies in Sub-Saharan Africa addressed high-burden conditions such as HIV/AIDS, tuberculosis, neglected tropical diseases and malaria, and diarrhea, lower respiratory infections, meningitis, and other common infectious diseases. Conclusion: The Global Health Cost-Effectiveness Analysis Registry reveals a growing and diverse field of cost-per-DALY averted studies. However, study methods and reporting practices have varied substantially.

Suggested Citation

  • Peter J Neumann & Teja Thorat & Yue Zhong & Jordan Anderson & Megan Farquhar & Mark Salem & Eileen Sandberg & Cayla J Saret & Colby Wilkinson & Joshua T Cohen, 2016. "A Systematic Review of Cost-Effectiveness Studies Reporting Cost-per-DALY Averted," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-14, December.
    • Handle: RePEc:plo:pone00:0168512
    DOI: 10.1371/journal.pone.0168512
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    References listed on IDEAS

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    1. Brecht Devleesschauwer & Arie Havelaar & Charline Maertens de Noordhout & Juanita Haagsma & Nicolas Praet & Pierre Dorny & Luc Duchateau & Paul Torgerson & Herman Oyen & Niko Speybroeck, 2014. "DALY calculation in practice: a stepwise approach," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 59(3), pages 571-574, June.
    2. Thorat, Teja & Cangelosi, Michael & Neumann, Peter J., 2012. "Skills of the Trade: The Tufts Cost-Effectiveness Analysis Registry," Journal of Benefit-Cost Analysis, Cambridge University Press, vol. 3(1), pages 1-9, January.
    3. Thorat Teja & Cangelosi Michael & Neumann Peter J., 2012. "Skills of the Trade: The Tufts Cost-Effectiveness Analysis Registry," Journal of Benefit-Cost Analysis, De Gruyter, vol. 3(1), pages 1-9, January.
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    3. Nafiseh Shamsi Gamchi & S. Ali Torabi & Fariborz Jolai, 2021. "A novel vehicle routing problem for vaccine distribution using SIR epidemic model," OR Spectrum: Quantitative Approaches in Management, Springer;Gesellschaft für Operations Research e.V., vol. 43(1), pages 155-188, March.
    4. Błażej Łyszczarz & Karolina Sowa, 2022. "Production losses due to mortality associated with modifiable health risk factors in Poland," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 23(1), pages 33-45, February.
    5. Quang Dang Nguyen & Mikhail Prokopenko, 2022. "A general framework for optimising cost-effectiveness of pandemic response under partial intervention measures," Papers 2205.08996, arXiv.org, revised Nov 2022.
    6. Brian W. Weir & Jennifer Cantrell & David R. Holtgrave & Marisa S. Greenberg & Ryan D. Kennedy & Jessica M. Rath & Elizabeth C. Hair & Donna Vallone, 2018. "Cost and Threshold Analysis of the FinishIt Campaign to Prevent Youth Smoking in the United States," IJERPH, MDPI, vol. 15(8), pages 1-7, August.
    7. N. Shamsi Gamchi & M. Esmaeili, 2023. "A novel mathematical model for prioritization of individuals to receive vaccine considering governmental health protocols," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 24(4), pages 633-646, June.
    8. Ari D. Panzer & Joanna G. Emerson & Brittany D'Cruz & Avnee Patel & Saudamini Dabak & Wanrudee Isaranuwatchai & Yot Teerawattananon & Daniel A. Ollendorf & Peter J. Neumann & David D. Kim, 2020. "Growth and capacity for cost‐effectiveness analysis in Africa," Health Economics, John Wiley & Sons, Ltd., vol. 29(8), pages 945-954, August.
    9. Banke-Thomas, Aduragbemi & Nieuwenhuis, Sonja & Ologun, Adesoji & Mortimore, Gordon & Mpakateni, Martin, 2019. "Embedding value-for-money in practice: A case study of a health pooled fund programme implemented in conflict-affected South Sudan," Evaluation and Program Planning, Elsevier, vol. 77(C).

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