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Variability of the Estimated Glomerular Filtration Rate in the First Year after Kidney Transplantation Is an Independent Risk Factor for Poor Renal Allograft Outcomes: A Retrospective Cohort Study

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  • Hoon Young Choi
  • Kyu Ha Huh
  • Jae Geun Lee
  • Mi Kyung Song
  • Myoung Soo Kim
  • Yu Seun Kim
  • Beom Seok Kim

Abstract

Renal function in the first year after kidney transplantation (KT) can predict long-term renal graft survival. This study investigated whether estimated glomerular filtration rate (eGFR) variability during the first year after KT is a risk factor for poor renal allograft outcomes. This retrospective cohort study included 3077 patients who underwent repeated eGFR measurements for 1 year after KT at Severance Hospital Transplantation Center between 1979 and 2012. The eGFR variability during the first year after KT was the predictor. The patients were divided into four quartile groups of eGFR variability according to the coefficient of variation for eGFR (eGFR-CV). We selected a cutoff of eGFR-CV for graft failure and performed the sensitivity analyses. The graft outcome was worse in the highest quartile group of eGFR variability than in the other groups among all patients (Q4: HR 1.631, 95% CI 1.278–2.081; p

Suggested Citation

  • Hoon Young Choi & Kyu Ha Huh & Jae Geun Lee & Mi Kyung Song & Myoung Soo Kim & Yu Seun Kim & Beom Seok Kim, 2016. "Variability of the Estimated Glomerular Filtration Rate in the First Year after Kidney Transplantation Is an Independent Risk Factor for Poor Renal Allograft Outcomes: A Retrospective Cohort Study," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-12, December.
    • Handle: RePEc:plo:pone00:0168337
    DOI: 10.1371/journal.pone.0168337
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    1. Contal, Cecile & O'Quigley, John, 1999. "An application of changepoint methods in studying the effect of age on survival in breast cancer," Computational Statistics & Data Analysis, Elsevier, vol. 30(3), pages 253-270, May.
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