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Molecular insights into Sertoli cell function: how do metabolic disorders in childhood and adolescence affect spermatogonial fate?

Author

Listed:
  • Rossella Cannarella

    (University of Catania
    Cleveland Clinic Foundation)

  • Roberto Curto

    (University of Catania)

  • Rosita A. Condorelli

    (University of Catania)

  • Scott D. Lundy

    (Cleveland Clinic Foundation)

  • Sandro La Vignera

    (University of Catania)

  • Aldo E. Calogero

    (University of Catania)

Abstract

Male infertility is a major public health concern globally with unknown etiology in approximately half of cases. The decline in total sperm count over the past four decades and the parallel increase in childhood obesity may suggest an association between these two conditions. Here, we review the molecular mechanisms through which obesity during childhood and adolescence may impair future testicular function. Several mechanisms occurring in obesity can interfere with the delicate metabolic processes taking place at the testicular level during childhood and adolescence, providing the molecular substrate to hypothesize a causal relationship between childhood obesity and the risk of low sperm counts in adulthood.

Suggested Citation

  • Rossella Cannarella & Roberto Curto & Rosita A. Condorelli & Scott D. Lundy & Sandro La Vignera & Aldo E. Calogero, 2024. "Molecular insights into Sertoli cell function: how do metabolic disorders in childhood and adolescence affect spermatogonial fate?," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49765-1
    DOI: 10.1038/s41467-024-49765-1
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    References listed on IDEAS

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    1. Thomas W Kelsey & Amy Miles & Rod T Mitchell & Richard A Anderson & W Hamish B Wallace, 2016. "A Normative Model of Serum Inhibin B in Young Males," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-10, April.
    2. Sung Hee Um & Francesca Frigerio & Mitsuhiro Watanabe & Frédéric Picard & Manel Joaquin & Melanie Sticker & Stefano Fumagalli & Peter R. Allegrini & Sara C. Kozma & Johan Auwerx & George Thomas, 2004. "Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity," Nature, Nature, vol. 431(7005), pages 200-205, September.
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