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Magnetic Particle / Magnetic Resonance Imaging: In-Vitro MPI-Guided Real Time Catheter Tracking and 4D Angioplasty Using a Road Map and Blood Pool Tracer Approach

Author

Listed:
  • Johannes Salamon
  • Martin Hofmann
  • Caroline Jung
  • Michael Gerhard Kaul
  • Franziska Werner
  • Kolja Them
  • Rudolph Reimer
  • Peter Nielsen
  • Annika vom Scheidt
  • Gerhard Adam
  • Tobias Knopp
  • Harald Ittrich

Abstract

Purpose: In-vitro evaluation of the feasibility of 4D real time tracking of endovascular devices and stenosis treatment with a magnetic particle imaging (MPI) / magnetic resonance imaging (MRI) road map approach and an MPI-guided approach using a blood pool tracer. Materials and Methods: A guide wire and angioplasty-catheter were labeled with a thin layer of magnetic lacquer. For real time MPI a custom made software framework was developed. A stenotic vessel phantom filled with saline or superparamagnetic iron oxide nanoparticles (MM4) was equipped with bimodal fiducial markers for co-registration in preclinical 7T MRI and MPI. In-vitro angioplasty was performed inflating the balloon with saline or MM4. MPI data were acquired using a field of view of 37.3×37.3×18.6 mm3 and a frame rate of 46 volumes/sec. Analysis of the magnetic lacquer-marks on the devices were performed with electron microscopy, atomic absorption spectrometry and micro-computed tomography. Results: Magnetic marks allowed for MPI/MRI guidance of interventional devices. Bimodal fiducial markers enable MPI/MRI image fusion for MRI based roadmapping. MRI roadmapping and the blood pool tracer approach facilitate MPI real time monitoring of in-vitro angioplasty. Successful angioplasty was verified with MPI and MRI. Magnetic marks consist of micrometer sized ferromagnetic plates mainly composed of iron and iron oxide. Conclusions: 4D real time MP imaging, tracking and guiding of endovascular instruments and in-vitro angioplasty is feasible. In addition to an approach that requires a blood pool tracer, MRI based roadmapping might emerge as a promising tool for radiation free 4D MPI-guided interventions.

Suggested Citation

  • Johannes Salamon & Martin Hofmann & Caroline Jung & Michael Gerhard Kaul & Franziska Werner & Kolja Them & Rudolph Reimer & Peter Nielsen & Annika vom Scheidt & Gerhard Adam & Tobias Knopp & Harald It, 2016. "Magnetic Particle / Magnetic Resonance Imaging: In-Vitro MPI-Guided Real Time Catheter Tracking and 4D Angioplasty Using a Road Map and Blood Pool Tracer Approach," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-14, June.
    • Handle: RePEc:plo:pone00:0156899
    DOI: 10.1371/journal.pone.0156899
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    References listed on IDEAS

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    1. Bernhard Gleich & Jürgen Weizenecker, 2005. "Tomographic imaging using the nonlinear response of magnetic particles," Nature, Nature, vol. 435(7046), pages 1214-1217, June.
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