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Spatially selective delivery of living magnetic microrobots through torque-focusing

Author

Listed:
  • Nima Mirkhani

    (ETH Zurich)

  • Michael G. Christiansen

    (ETH Zurich)

  • Tinotenda Gwisai

    (ETH Zurich)

  • Stefano Menghini

    (ETH Zurich)

  • Simone Schuerle

    (ETH Zurich)

Abstract

Rotating magnetic fields enable biomedical microrobots to overcome physiological barriers and promote extravasation and accumulation in tumors. Nevertheless, targeting deeply situated tumors requires suppression of off-target actuation in healthy tissue. Here, we investigate a control strategy for applying spatially selective torque density to microrobots by combining rotating fields with magnetostatic selection fields. Taking magnetotactic bacteria as diffuse torque-based actuators, we numerically model off-target torque suppression, indicating the feasibility of centimeter to millimeter resolution for human applications. We study focal torque application in vitro, observing off-target suppression of actuation-dependent effects such as colonization of bacteria in tumor spheroids. We then design and construct a mouse-scale torque-focusing apparatus capable of maneuvering the focal point. Applying this system to a mouse tumor model increased accumulation of intravenously injected bacteria within tumors receiving focused actuation compared to non-actuated or globally actuated groups. This control scheme combines the advantages of torque-based actuation with spatial targeting.

Suggested Citation

  • Nima Mirkhani & Michael G. Christiansen & Tinotenda Gwisai & Stefano Menghini & Simone Schuerle, 2024. "Spatially selective delivery of living magnetic microrobots through torque-focusing," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46407-4
    DOI: 10.1038/s41467-024-46407-4
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    References listed on IDEAS

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    1. Christine K. Schmidt & Mariana Medina-Sánchez & Richard J. Edmondson & Oliver G. Schmidt, 2020. "Engineering microrobots for targeted cancer therapies from a medical perspective," Nature Communications, Nature, vol. 11(1), pages 1-18, December.
    2. T. O. Tasci & P. S. Herson & K. B. Neeves & D. W. M. Marr, 2016. "Surface-enabled propulsion and control of colloidal microwheels," Nature Communications, Nature, vol. 7(1), pages 1-6, April.
    3. Bernhard Gleich & Jürgen Weizenecker, 2005. "Tomographic imaging using the nonlinear response of magnetic particles," Nature, Nature, vol. 435(7046), pages 1214-1217, June.
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