IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0155124.html
   My bibliography  Save this article

Mathematical Modeling Predicts that Increased HSV-2 Shedding in HIV-1 Infected Persons Is Due to Poor Immunologic Control in Ganglia and Genital Mucosa

Author

Listed:
  • Joshua T Schiffer
  • David A Swan
  • Amalia Magaret
  • Timothy W Schacker
  • Anna Wald
  • Lawrence Corey

Abstract

A signature feature of HIV infection is poor control of herpes virus infections, which reactivate from latency and cause opportunistic infections. While the general mechanism underlying this observation is deficient CD4+T-cell function, it is unknown whether increased severity of herpes virus infections is due primarily to poor immune control in latent or lytic sites of infection, or whether CD4+ immunodeficiency leads to more critical downstream deficits in humoral or cell-mediated immunologic responses. Here we compare genital shedding patterns of herpes simplex virus-2 (HSV-2) in 98 HIV infected and 98 HIV uninfected men matched on length of infection, HSV-1 serostatus and nationality. We demonstrate that high copy HSV-2 shedding is more frequent in HIV positive men, particularly in participants with CD4+ T-cell count

Suggested Citation

  • Joshua T Schiffer & David A Swan & Amalia Magaret & Timothy W Schacker & Anna Wald & Lawrence Corey, 2016. "Mathematical Modeling Predicts that Increased HSV-2 Shedding in HIV-1 Infected Persons Is Due to Poor Immunologic Control in Ganglia and Genital Mucosa," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-22, June.
    • Handle: RePEc:plo:pone00:0155124
    DOI: 10.1371/journal.pone.0155124
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155124
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155124&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0155124?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Haina Shin & Akiko Iwasaki, 2012. "A vaccine strategy that protects against genital herpes by establishing local memory T cells," Nature, Nature, vol. 491(7424), pages 463-467, November.
    2. Jia Zhu & Tao Peng & Christine Johnston & Khamsone Phasouk & Angela S. Kask & Alexis Klock & Lei Jin & Kurt Diem & David M. Koelle & Anna Wald & Harlan Robins & Lawrence Corey, 2013. "Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection," Nature, Nature, vol. 497(7450), pages 494-497, May.
    3. Varsha Dhankani & J Nathan Kutz & Joshua T Schiffer, 2014. "Herpes Simplex Virus-2 Genital Tract Shedding Is Not Predictable over Months or Years in Infected Persons," PLOS Computational Biology, Public Library of Science, vol. 10(11), pages 1-16, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jia He & Chaoyu Wang & Xiao Fang & Junyao Li & Xueying Shen & Junxia Zhang & Cheng Peng & Hongjian Li & Sai Li & Jeffrey M. Karp & Rui Kuai, 2024. "Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Anneliese S. Ashhurst & Matt D. Johansen & Joshua W. C. Maxwell & Skye Stockdale & Caroline L. Ashley & Anupriya Aggarwal & Rezwan Siddiquee & Stefan Miemczyk & Duc H. Nguyen & Joel P. Mackay & Claudi, 2022. "Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Sijie Sun & Lei Jin & Ying Zheng & Jia Zhu, 2022. "Modeling human HSV infection via a vascularized immune-competent skin-on-chip platform," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Hongbin Wang & Carol Hoffman & Xinghong Yang & Beata Clapp & David W Pascual, 2020. "Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection," PLOS Pathogens, Public Library of Science, vol. 16(1), pages 1-31, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0155124. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.