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Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection

Author

Listed:
  • Jia Zhu

    (University of Washington
    Fred Hutchinson Cancer Research Center)

  • Tao Peng

    (Fred Hutchinson Cancer Research Center
    University of Washington)

  • Christine Johnston

    (University of Washington)

  • Khamsone Phasouk

    (Fred Hutchinson Cancer Research Center)

  • Angela S. Kask

    (University of Washington)

  • Alexis Klock

    (University of Washington)

  • Lei Jin

    (University of Washington)

  • Kurt Diem

    (University of Washington)

  • David M. Koelle

    (University of Washington
    Fred Hutchinson Cancer Research Center
    University of Washington
    University of Washington)

  • Anna Wald

    (University of Washington
    Fred Hutchinson Cancer Research Center
    University of Washington
    University of Washington)

  • Harlan Robins

    (Program in Computational Biology, Fred Hutchinson Cancer Research Center)

  • Lawrence Corey

    (University of Washington
    Fred Hutchinson Cancer Research Center
    University of Washington
    University of Washington)

Abstract

Herpes simplex virus 2-infected individuals are shown to have skin-tissue-resident CD8αα+ T cells that persist at the portal of virus release in genital skin and mucosa, possess oligoclonal T-cell-receptor-β CDR3 sequences that are stable over time, and express gene signatures of antiviral and cytolytic function indicative of viral-specific immune surveillance.

Suggested Citation

  • Jia Zhu & Tao Peng & Christine Johnston & Khamsone Phasouk & Angela S. Kask & Alexis Klock & Lei Jin & Kurt Diem & David M. Koelle & Anna Wald & Harlan Robins & Lawrence Corey, 2013. "Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection," Nature, Nature, vol. 497(7450), pages 494-497, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7450:d:10.1038_nature12110
    DOI: 10.1038/nature12110
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    Citations

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    Cited by:

    1. Joshua T Schiffer & David A Swan & Amalia Magaret & Timothy W Schacker & Anna Wald & Lawrence Corey, 2016. "Mathematical Modeling Predicts that Increased HSV-2 Shedding in HIV-1 Infected Persons Is Due to Poor Immunologic Control in Ganglia and Genital Mucosa," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-22, June.
    2. Sijie Sun & Lei Jin & Ying Zheng & Jia Zhu, 2022. "Modeling human HSV infection via a vascularized immune-competent skin-on-chip platform," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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