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A vaccine strategy that protects against genital herpes by establishing local memory T cells

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  • Haina Shin

    (Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA)

  • Akiko Iwasaki

    (Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA)

Abstract

A genital herpes simplex vaccine strategy of immunization using attenuated virus with peripheral local chemokine application can establish a population of protective tissue-resident memory T cells.

Suggested Citation

  • Haina Shin & Akiko Iwasaki, 2012. "A vaccine strategy that protects against genital herpes by establishing local memory T cells," Nature, Nature, vol. 491(7424), pages 463-467, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7424:d:10.1038_nature11522
    DOI: 10.1038/nature11522
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    Cited by:

    1. Jia He & Chaoyu Wang & Xiao Fang & Junyao Li & Xueying Shen & Junxia Zhang & Cheng Peng & Hongjian Li & Sai Li & Jeffrey M. Karp & Rui Kuai, 2024. "Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Joshua T Schiffer & David A Swan & Amalia Magaret & Timothy W Schacker & Anna Wald & Lawrence Corey, 2016. "Mathematical Modeling Predicts that Increased HSV-2 Shedding in HIV-1 Infected Persons Is Due to Poor Immunologic Control in Ganglia and Genital Mucosa," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-22, June.
    3. Anneliese S. Ashhurst & Matt D. Johansen & Joshua W. C. Maxwell & Skye Stockdale & Caroline L. Ashley & Anupriya Aggarwal & Rezwan Siddiquee & Stefan Miemczyk & Duc H. Nguyen & Joel P. Mackay & Claudi, 2022. "Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Hongbin Wang & Carol Hoffman & Xinghong Yang & Beata Clapp & David W Pascual, 2020. "Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection," PLOS Pathogens, Public Library of Science, vol. 16(1), pages 1-31, January.

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