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Preoperative Plasma Fibrinogen Level Represents an Independent Prognostic Factor in a Chinese Cohort of Patients with Upper Tract Urothelial Carcinoma

Author

Listed:
  • Bo Zhang
  • Yi Song
  • Jie Jin
  • Li-Qun Zhou
  • Zhi-Song He
  • Cheng Shen
  • Qun He
  • Jun Li
  • Li-Bo Liu
  • Cong Wang
  • Xiao-Yu Chen
  • Yu Fan
  • Shuai Hu
  • Lei Zhang
  • Wei Yu
  • Wen-Ke Han

Abstract

Background: Increased plasma fibrinogen is thought to contribute to tumor progression and metastasis. The association of plasma fibrinogen with clinicopathological characteristics, and the optimal cutoff with an ideal predictive value has not been fully determined in patients with upper tract urothelial carcinoma (UTUC). We aimed to investigate the clinical significance of this parameter in a Chinese cohort of patients with UTUC. Methods: A retrospective study was conducted to analyze the clinical data of 184 operable UTUC patients in a Chinese cohort with a high incidence of chronic kidney disease (CKD). An optimal cutoff was set for further analysis according to validated web-based software. The associations of plasma fibrinogen with clinicopathological characteristics and survival were assessed. Multivariate analyses were performed to determine the independent prognostic factors. Results: Elevated plasma fibrinogen was significantly associated with tumor necrosis, lymph node involvement, and a higher preoperative CKD stage, pathological tumor stage and grade (all P

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  • Bo Zhang & Yi Song & Jie Jin & Li-Qun Zhou & Zhi-Song He & Cheng Shen & Qun He & Jun Li & Li-Bo Liu & Cong Wang & Xiao-Yu Chen & Yu Fan & Shuai Hu & Lei Zhang & Wei Yu & Wen-Ke Han, 2016. "Preoperative Plasma Fibrinogen Level Represents an Independent Prognostic Factor in a Chinese Cohort of Patients with Upper Tract Urothelial Carcinoma," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-12, March.
    • Handle: RePEc:plo:pone00:0150193
    DOI: 10.1371/journal.pone.0150193
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    References listed on IDEAS

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    1. Jan Budczies & Frederick Klauschen & Bruno V Sinn & Balázs Győrffy & Wolfgang D Schmitt & Silvia Darb-Esfahani & Carsten Denkert, 2012. "Cutoff Finder: A Comprehensive and Straightforward Web Application Enabling Rapid Biomarker Cutoff Optimization," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
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