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Ischemic Preconditioning in the Animal Kidney, a Systematic Review and Meta-Analysis

Author

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  • Kimberley E Wever
  • Theo P Menting
  • Maroeska Rovers
  • J Adam van der Vliet
  • Gerard A Rongen
  • Rosalinde Masereeuw
  • Merel Ritskes-Hoitinga
  • Carlijn R Hooijmans
  • Michiel Warlé

Abstract

Ischemic preconditioning (IPC) is a potent renoprotective strategy which has not yet been translated successfully into clinical practice, in spite of promising results in animal studies. We performed a unique systematic review and meta-analysis of animal studies to identify factors modifying IPC efficacy in renal ischemia/reperfusion injury (IRI), in order to enhance the design of future (clinical) studies. An electronic literature search for animal studies on IPC in renal IRI yielded fifty-eight studies which met our inclusion criteria. We extracted data for serum creatinine, blood urea nitrogen and histological renal damage, as well as study quality indicators. Meta-analysis showed that IPC reduces serum creatinine (SMD 1.54 [95%CI 1.16, 1.93]), blood urea nitrogen (SMD 1.42 [95% CI 0.97, 1.87]) and histological renal damage (SMD 1.12 [95% CI 0.89, 1.35]) after IRI as compared to controls. Factors influencing IPC efficacy were the window of protection (

Suggested Citation

  • Kimberley E Wever & Theo P Menting & Maroeska Rovers & J Adam van der Vliet & Gerard A Rongen & Rosalinde Masereeuw & Merel Ritskes-Hoitinga & Carlijn R Hooijmans & Michiel Warlé, 2012. "Ischemic Preconditioning in the Animal Kidney, a Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-10, February.
    • Handle: RePEc:plo:pone00:0032296
    DOI: 10.1371/journal.pone.0032296
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    Cited by:

    1. Nienke A Hesen & Niels P Riksen & Bart Aalders & Merel Ritskes-Hoitinga & Saloua El Messaoudi & Kimberley E Wever, 2017. "A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-18, August.
    2. Simone J Jonker & Theo P Menting & Michiel C Warlé & Merel Ritskes-Hoitinga & Kimberley E Wever, 2016. "Preclinical Evidence for the Efficacy of Ischemic Postconditioning against Renal Ischemia-Reperfusion Injury, a Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-19, March.
    3. Kimberley E Wever & Carlijn R Hooijmans & Niels P Riksen & Thomas B Sterenborg & Emily S Sena & Merel Ritskes-Hoitinga & Michiel C Warlé, 2015. "Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-17, November.

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