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The SNP rs931794 in 15q25.1 Is Associated with Lung Cancer Risk: A Hospital-Based Case-Control Study and Meta-Analysis

Author

Listed:
  • Qi Wang
  • Juntao Ke
  • Qibin Song
  • Weiguo Hu
  • Xuzai Lu
  • Zhenling Wang
  • Hongyun Gong
  • Tangpeng Xu
  • Xueqin Chen
  • Bin Xu
  • Cheng Liu
  • Yun Sun
  • Yajie Gong
  • Yang Yang
  • Ying Zhu

Abstract

Background: Lung cancer is one of the most common human malignant diseases and the leading cause of cancer death worldwide. The rs931794, a SNP located in 15q25.1, has been suggested to be associated with lung cancer risk. Nevertheless, several genetic association studies yielded controversial results. Methods and Findings: A hospital-based case-control study involving 611 cases and 1062 controls revealed the variant of rs931794 was related to increased lung cancer risk. Stratified analyses revealed the G allele was significantly associated with lung cancer risk among smokers. Following meta-analysis including 6616 cases and 7697 controls confirmed the relevance of rs931794 variant with increased lung cancer risk once again. Heterogeneity should be taken into account when interpreting the consequences. Stratified analysis found ethnicity, histological type and genotyping method were not the sources of between-study heterogeneity. Further sensitivity analysis revealed that the study “Hsiung et al (2010)” might be the major contributor to heterogeneity. Cumulative meta-analysis showed the trend was increasingly obvious with adding studies, confirming the significant association. Conclusions: Results from our current case-control study and meta-analysis offered insight of association between rs931794 and lung cancer risk, suggesting the variant of rs931794 might be related with increased lung cancer risk.

Suggested Citation

  • Qi Wang & Juntao Ke & Qibin Song & Weiguo Hu & Xuzai Lu & Zhenling Wang & Hongyun Gong & Tangpeng Xu & Xueqin Chen & Bin Xu & Cheng Liu & Yun Sun & Yajie Gong & Yang Yang & Ying Zhu, 2015. "The SNP rs931794 in 15q25.1 Is Associated with Lung Cancer Risk: A Hospital-Based Case-Control Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0128201
    DOI: 10.1371/journal.pone.0128201
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    References listed on IDEAS

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    1. Bian Wu & Hong-Li Liu & Sheng Zhang & Xiao-Rong Dong & Gang Wu, 2012. "Lack of an Association between Two BER Gene Polymorphisms and Breast Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    3. Mingliang Gu & Xiaoqun Dong & Xuezhi Zhang & Xumin Wang & Yue Qi & Jun Yu & Wenquan Niu, 2012. "Strong Association between Two Polymorphisms on 15q25.1 and Lung Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-8, June.
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