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Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants versus Vitamin K Antagonist Oral Anticoagulants in Patients Undergoing Radiofrequency Catheter Ablation of Atrial Fibrillation: A Meta-Analysis

Author

Listed:
  • Giuseppe Santarpia
  • Salvatore De Rosa
  • Alberto Polimeni
  • Salvatore Giampà
  • Mariella Micieli
  • Antonio Curcio
  • Ciro Indolfi

Abstract

Background: Use of the non-vitamin K antagonist oral anticoagulants (NOACs) is endorsed by current guidelines for stroke prevention in patients with atrial fibrillation (AF). However efficacy and safety of NOACs in patients undergoing catheter ablation (RFCA) of AF has not been well established yet. Objectives: To perform a meta-analysis of all studies comparing NOACs and vitamin K antagonist oral anticoagulants (VKAs) in patients undergoing RFCA. Data Sources: Studies were searched for in PubMed and Google Scholar databases. Study Eligibility Criteria: Studies were considered eligible if: they evaluated the clinical impact of NOACs versus VKAs; they specifically analyzed the use of anticoagulants during periprocedural phase of RFCA; they reported clinical outcome data. Study Appraisal and Synthesis Methods: 25 studies were selected, including 9881 cases. The summary measure used was the risk ratio (RR) with 95% confidence interval (CI). The random-effects or the fixed effect model were used to synthesize results from the selected studies. Results: There was no significant difference in thromboembolic complications (RR 1.39; p=0.13). Bleeding complications were significantly lower in the NOACs-treated arm as compared to VKAs (RR=0.67, p

Suggested Citation

  • Giuseppe Santarpia & Salvatore De Rosa & Alberto Polimeni & Salvatore Giampà & Mariella Micieli & Antonio Curcio & Ciro Indolfi, 2015. "Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants versus Vitamin K Antagonist Oral Anticoagulants in Patients Undergoing Radiofrequency Catheter Ablation of Atrial Fibrillation: A Me," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-18, May.
    • Handle: RePEc:plo:pone00:0126512
    DOI: 10.1371/journal.pone.0126512
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. Salvatore De Rosa & Jolanda Sabatino & Alberto Polimeni & Sabato Sorrentino & Ciro Indolfi, 2020. "Dual anti-thrombotic treatment with direct anticoagulants improves clinical outcomes in patients with Atrial Fibrillation with ACS or undergoing PCI. A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-11, July.

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