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Exploring the Genetic Signature of Body Size in Yucatan Miniature Pig

Author

Listed:
  • Hyeongmin Kim
  • Ki Duk Song
  • Hyeon Jeong Kim
  • WonCheoul Park
  • Jaemin Kim
  • Taeheon Lee
  • Dong-Hyun Shin
  • Woori Kwak
  • Young-jun Kwon
  • Samsun Sung
  • Sunjin Moon
  • Kyung-Tai Lee
  • Namshin Kim
  • Joon Ki Hong
  • Kyung Yeon Eo
  • Kang Seok Seo
  • Girak Kim
  • Sungmoo Park
  • Cheol-Heui Yun
  • Hyunil Kim
  • Kimyung Choi
  • Jiho Kim
  • Woon Kyu Lee
  • Duk-Kyung Kim
  • Jae-Don Oh
  • Eui-Soo Kim
  • Seoae Cho
  • Hak-Kyo Lee
  • Tae-Hun Kim
  • Heebal Kim

Abstract

Since being domesticated about 10,000–12,000 years ago, domestic pigs (Sus scrofa domesticus) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature pigs have been selected for small body size to withstand high temperature environment and for laboratory use. This renders the Yucatan miniature pig a valuable model for understanding the evolution of body size. We investigate the genetic signature for selection of body size in the Yucatan miniature pig. Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar). By estimating the XP-EHH statistic using re-sequencing data derived from 70 pigs, we were able to unravel the signatures of selection of body size. We found that both selections at the level of organism, and at the cellular level have occurred. Selection at the higher levels include feed intake, regulation of body weight and increase in mass while selection at the molecular level includes cell cycle and cell proliferation. Positively selected genes probed by XP-EHH may provide insight into the docile character and innate immunity as well as body size of Yucatan miniature pig.

Suggested Citation

  • Hyeongmin Kim & Ki Duk Song & Hyeon Jeong Kim & WonCheoul Park & Jaemin Kim & Taeheon Lee & Dong-Hyun Shin & Woori Kwak & Young-jun Kwon & Samsun Sung & Sunjin Moon & Kyung-Tai Lee & Namshin Kim & Joo, 2015. "Exploring the Genetic Signature of Body Size in Yucatan Miniature Pig," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-16, April.
    • Handle: RePEc:plo:pone00:0121732
    DOI: 10.1371/journal.pone.0121732
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    1. Pardis C. Sabeti & Patrick Varilly & Ben Fry & Jason Lohmueller & Elizabeth Hostetter & Chris Cotsapas & Xiaohui Xie & Elizabeth H. Byrne & Steven A. McCarroll & Rachelle Gaudet & Stephen F. Schaffner, 2007. "Genome-wide detection and characterization of positive selection in human populations," Nature, Nature, vol. 449(7164), pages 913-918, October.
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