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Model Selection Emphasises the Importance of Non-Chromosomal Information in Genetic Studies

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  • Reda Rawi
  • Mohamed El Anbari
  • Halima Bensmail

Abstract

Ever since the case of the missing heritability was highlighted some years ago, scientists have been investigating various possible explanations for the issue. However, none of these explanations include non-chromosomal genetic information. Here we describe explicitly how chromosomal and non-chromosomal modifiers collectively influence the heritability of a trait, in this case, the growth rate of yeast. Our results show that the non-chromosomal contribution can be large, adding another dimension to the estimation of heritability. We also discovered, combining the strength of LASSO with model selection, that the interaction of chromosomal and non-chromosomal information is essential in describing phenotypes.

Suggested Citation

  • Reda Rawi & Mohamed El Anbari & Halima Bensmail, 2015. "Model Selection Emphasises the Importance of Non-Chromosomal Information in Genetic Studies," PLOS ONE, Public Library of Science, vol. 10(1), pages 1-10, January.
    • Handle: RePEc:plo:pone00:0117014
    DOI: 10.1371/journal.pone.0117014
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    References listed on IDEAS

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    1. Lars M. Steinmetz & Himanshu Sinha & Dan R. Richards & Jamie I. Spiegelman & Peter J. Oefner & John H. McCusker & Ronald W. Davis, 2002. "Dissecting the architecture of a quantitative trait locus in yeast," Nature, Nature, vol. 416(6878), pages 326-330, March.
    2. Joshua S. Bloom & Ian M. Ehrenreich & Wesley T. Loo & Thúy-Lan Võ Lite & Leonid Kruglyak, 2013. "Finding the sources of missing heritability in a yeast cross," Nature, Nature, vol. 494(7436), pages 234-237, February.
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