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Finding the sources of missing heritability in a yeast cross

Author

Listed:
  • Joshua S. Bloom

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Ian M. Ehrenreich

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Molecular and Computational Biology Section, University of Southern California)

  • Wesley T. Loo

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Thúy-Lan Võ Lite

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Leonid Kruglyak

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University
    Howard Hughes Medical Institute, Princeton University)

Abstract

In a cross between two yeast strains, detected loci are found to explain nearly the entire additive contribution to heritable variation for a number of quantitative traits.

Suggested Citation

  • Joshua S. Bloom & Ian M. Ehrenreich & Wesley T. Loo & Thúy-Lan Võ Lite & Leonid Kruglyak, 2013. "Finding the sources of missing heritability in a yeast cross," Nature, Nature, vol. 494(7436), pages 234-237, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11867
    DOI: 10.1038/nature11867
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    Citations

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    Cited by:

    1. Zhengcao Li & Henner Simianer, 2020. "Pan-genomic open reading frames: A potential supplement of single nucleotide polymorphisms in estimation of heritability and genomic prediction," PLOS Genetics, Public Library of Science, vol. 16(8), pages 1-19, August.
    2. Gaotian Zhang & Nicole M. Roberto & Daehan Lee & Steffen R. Hahnel & Erik C. Andersen, 2022. "The impact of species-wide gene expression variation on Caenorhabditis elegans complex traits," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Reda Rawi & Mohamed El Anbari & Halima Bensmail, 2015. "Model Selection Emphasises the Importance of Non-Chromosomal Information in Genetic Studies," PLOS ONE, Public Library of Science, vol. 10(1), pages 1-10, January.
    4. Takeshi Matsui & Martin N. Mullis & Kevin R. Roy & Joseph J. Hale & Rachel Schell & Sasha F. Levy & Ian M. Ehrenreich, 2022. "The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Andreas Wagner, 2015. "Causal Drift, Robust Signaling, and Complex Disease," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-29, March.

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