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Network Meta-Analysis Using R: A Review of Currently Available Automated Packages

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  • Binod Neupane
  • Danielle Richer
  • Ashley Joel Bonner
  • Taddele Kibret
  • Joseph Beyene

Abstract

Network meta-analysis (NMA) – a statistical technique that allows comparison of multiple treatments in the same meta-analysis simultaneously – has become increasingly popular in the medical literature in recent years. The statistical methodology underpinning this technique and software tools for implementing the methods are evolving. Both commercial and freely available statistical software packages have been developed to facilitate the statistical computations using NMA with varying degrees of functionality and ease of use. This paper aims to introduce the reader to three R packages, namely, gemtc, pcnetmeta, and netmeta, which are freely available software tools implemented in R. Each automates the process of performing NMA so that users can perform the analysis with minimal computational effort. We present, compare and contrast the availability and functionality of different important features of NMA in these three packages so that clinical investigators and researchers can determine which R packages to implement depending on their analysis needs. Four summary tables detailing (i) data input and network plotting, (ii) modeling options, (iii) assumption checking and diagnostic testing, and (iv) inference and reporting tools, are provided, along with an analysis of a previously published dataset to illustrate the outputs available from each package. We demonstrate that each of the three packages provides a useful set of tools, and combined provide users with nearly all functionality that might be desired when conducting a NMA.

Suggested Citation

  • Binod Neupane & Danielle Richer & Ashley Joel Bonner & Taddele Kibret & Joseph Beyene, 2014. "Network Meta-Analysis Using R: A Review of Currently Available Automated Packages," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-17, December.
    • Handle: RePEc:plo:pone00:0115065
    DOI: 10.1371/journal.pone.0115065
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    References listed on IDEAS

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    1. Adriani Nikolakopoulou & Anna Chaimani & Areti Angeliki Veroniki & Haris S Vasiliadis & Christopher H Schmid & Georgia Salanti, 2014. "Characteristics of Networks of Interventions: A Description of a Database of 186 Published Networks," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-10, January.
    2. Sofia Dias & Alex J. Sutton & A. E. Ades & Nicky J. Welton, 2013. "Evidence Synthesis for Decision Making 2," Medical Decision Making, , vol. 33(5), pages 607-617, July.
    3. Sofia Dias & Alex J. Sutton & Nicky J. Welton & A. E. Ades, 2013. "Evidence Synthesis for Decision Making 6," Medical Decision Making, , vol. 33(5), pages 671-678, July.
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