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Pharmacological Interventions for Acceleration of the Onset Time of Rocuronium: A Meta-Analysis

Author

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  • Jing Dong
  • Lingqi Gao
  • Wenqing Lu
  • Zifeng Xu
  • Jijian Zheng

Abstract

Background: Rocuronium is an acceptable alternative when succinylcholine is contraindicated for facilitating the endotracheal intubation. However, the onset time of rocuronium for good intubation condition is still slower than that condition of succinylcholine. This study systematically investigated the most efficacious pharmacological interventions for accelerating the onset time of rocuronium. Methods: Medline, Embase, Cochrane Library databases, www.clinicaltrials.gov, and hand searching from the reference lists of identified papers were searched for randomized controlled trials comparing drug interventions with placebo or another drug to shorten the onset time of rocuronium. Statistical analyses were performed using RevMan5.2 and ADDIS 1.16.5 softwares. Mean differences (MDs) with their 95% confidence intervals (95% CIs) were used to analyze the effects of drug interventions on the onset time of rocuronium. Results: 43 randomized controlled trials with 2,465 patients were analyzed. The average onset time of rocuronium was 102.4±24.9 s. Priming with rocuronium [Mean difference (MD) −21.0 s, 95% confidence interval (95% CI) (−27.6 to −14.3 s)], pretreatment with ephedrine [−22.3 s (−29.1 to −15.5 s)], pretreatment with magnesium sulphate [−28.2 s (−50.9 to −5.6 s)] were all effective in reducing the onset time of rocuronium. Statistical testing of indirect comparisons showed that rocuronium priming, pretreatment with ephedrine, and pretreatment with magnesium sulphate had the similar efficacy. Conclusion: Rocuronium priming, pretreatment with ephedrine, and pretreatment with magnesium sulphate were all effective in accelerating the onset time of rocuronium, and furthermore their efficacies were similar. Considering the convenience and efficacy, priming with rocuronium is recommended for accelerating the onset time of rocuronium. However, more strict clinical trials are still needed to reach a more solid conclusion due to the large heterogeneities exist among different studies.

Suggested Citation

  • Jing Dong & Lingqi Gao & Wenqing Lu & Zifeng Xu & Jijian Zheng, 2014. "Pharmacological Interventions for Acceleration of the Onset Time of Rocuronium: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-15, December.
    • Handle: RePEc:plo:pone00:0114231
    DOI: 10.1371/journal.pone.0114231
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    References listed on IDEAS

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    1. Unknown, 2004. "Table of Contents," International Food and Agribusiness Management Review, International Food and Agribusiness Management Association, vol. 7(4), pages 1-1.
    2. Unknown, 2004. "Table of Contents," International Food and Agribusiness Management Review, International Food and Agribusiness Management Association, vol. 7(2), pages 1-1.
    3. Lu, Guobing & Ades, A.E., 2006. "Assessing Evidence Inconsistency in Mixed Treatment Comparisons," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 447-459, June.
    4. Unknown, 2004. "Table of Contents," International Food and Agribusiness Management Review, International Food and Agribusiness Management Association, vol. 7(3), pages 1-1.
    5. Unknown, 2004. "Table of Contents," International Food and Agribusiness Management Review, International Food and Agribusiness Management Association, vol. 7(1), pages 1-1.
    6. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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