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Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Han Chinese Population: A Replication Study and Meta-Analysis

Author

Listed:
  • Yi-Cheng Chang
  • Pi-Hua Liu
  • Yu-Hsiang Yu
  • Shan-Shan Kuo
  • Tien-Jyun Chang
  • Yi-Der Jiang
  • Jiun-Yi Nong
  • Juey-Jen Hwang
  • Lee-Ming Chuang

Abstract

Background: Several genome-wide association studies (GWAS) involving European populations have successfully identified risk genetic variants associated with type 2 diabetes mellitus (T2DM). However, the effects conferred by these variants in Han Chinese population have not yet been fully elucidated. Methods: We analyzed the effects of 24 risk genetic variants with reported associations from European GWAS in 3,040 Han Chinese subjects in Taiwan (including 1,520 T2DM cases and 1,520 controls). The discriminative power of the prediction models with and without genotype scores was compared. We further meta-analyzed the association of these variants with T2DM by pooling all candidate-gene association studies conducted in Han Chinese. Results: Five risk variants in IGF2BP2 (rs4402960, rs1470579), CDKAL1 (rs10946398), SLC30A8 (rs13266634), and HHEX (rs1111875) genes were nominally associated with T2DM in our samples. The odds ratio was 2.22 (95% confidence interval, 1.81-2.73, P 34) as compared with subjects with the lowest quartile (score

Suggested Citation

  • Yi-Cheng Chang & Pi-Hua Liu & Yu-Hsiang Yu & Shan-Shan Kuo & Tien-Jyun Chang & Yi-Der Jiang & Jiun-Yi Nong & Juey-Jen Hwang & Lee-Ming Chuang, 2014. "Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Han Chinese Population: A Replication Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-8, April.
    • Handle: RePEc:plo:pone00:0095045
    DOI: 10.1371/journal.pone.0095045
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    References listed on IDEAS

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    1. Robert Sladek & Ghislain Rocheleau & Johan Rung & Christian Dina & Lishuang Shen & David Serre & Philippe Boutin & Daniel Vincent & Alexandre Belisle & Samy Hadjadj & Beverley Balkau & Barbara Heude &, 2007. "A genome-wide association study identifies novel risk loci for type 2 diabetes," Nature, Nature, vol. 445(7130), pages 881-885, February.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    Cited by:

    1. Ping Rao & Hao Wang & Honghong Fang & Qing Gao & Jie Zhang & Manshu Song & Yong Zhou & Youxin Wang & Wei Wang, 2016. "Association between IGF2BP2 Polymorphisms and Type 2 Diabetes Mellitus: A Case–Control Study and Meta-Analysis," IJERPH, MDPI, vol. 13(6), pages 1-13, June.
    2. Ping Rao & Yong Zhou & Si-Qi Ge & An-Xin Wang & Xin-Wei Yu & Mohamed Ali Alzain & Andrea Katherine Veronica & Jing Qiu & Man-Shu Song & Jie Zhang & Hao Wang & Hong-Hong Fang & Qing Gao & You-Xin Wang , 2016. "Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Northern Han Chinese," IJERPH, MDPI, vol. 13(9), pages 1-10, August.

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