IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0094411.html
   My bibliography  Save this article

An Agent-Based Model of the Response to Angioplasty and Bare-Metal Stent Deployment in an Atherosclerotic Blood Vessel

Author

Listed:
  • Antonia E Curtin
  • Leming Zhou

Abstract

Purpose: While animal models are widely used to investigate the development of restenosis in blood vessels following an intervention, computational models offer another means for investigating this phenomenon. A computational model of the response of a treated vessel would allow investigators to assess the effects of altering certain vessel- and stent-related variables. The authors aimed to develop a novel computational model of restenosis development following an angioplasty and bare-metal stent implantation in an atherosclerotic vessel using agent-based modeling techniques. The presented model is intended to demonstrate the body’s response to the intervention and to explore how different vessel geometries or stent arrangements may affect restenosis development. Methods: The model was created on a two-dimensional grid space. It utilizes the post-procedural vessel lumen diameter and stent information as its input parameters. The simulation starting point of the model is an atherosclerotic vessel after an angioplasty and stent implantation procedure. The model subsequently generates the final lumen diameter, percent change in lumen cross-sectional area, time to lumen diameter stabilization, and local concentrations of inflammatory cytokines upon simulation completion. Simulation results were directly compared with the results from serial imaging studies and cytokine levels studies in atherosclerotic patients from the relevant literature. Results: The final lumen diameter results were all within one standard deviation of the mean lumen diameters reported in the comparison studies. The overlapping-stent simulations yielded results that matched published trends. The cytokine levels remained within the range of physiological levels throughout the simulations. Conclusion: We developed a novel computational model that successfully simulated the development of restenosis in a blood vessel following an angioplasty and bare-metal stent deployment based on the characteristics of the vessel cross-section and stent. A further development of this model could ultimately be used as a predictive tool to depict patient outcomes and inform treatment options.

Suggested Citation

  • Antonia E Curtin & Leming Zhou, 2014. "An Agent-Based Model of the Response to Angioplasty and Bare-Metal Stent Deployment in an Atherosclerotic Blood Vessel," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-14, April.
  • Handle: RePEc:plo:pone00:0094411
    DOI: 10.1371/journal.pone.0094411
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094411
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094411&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0094411?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Katrin Wasser & Sonja Schnaudigel & Janin Wohlfahrt & Marios-Nikos Psychogios & Michael Knauth & Klaus Gröschel, 2011. "Inflammation and In-Stent Restenosis: The Role of Serum Markers and Stent Characteristics in Carotid Artery Stenting," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-6, July.
    2. Muaz Niazi & Amir Hussain, 2011. "Agent-based computing from multi-agent systems to agent-based models: a visual survey," Scientometrics, Springer;Akadémiai Kiadó, vol. 89(2), pages 479-499, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ping Xie, 2015. "Study of international anticancer research trends via co-word and document co-citation visualization analysis," Scientometrics, Springer;Akadémiai Kiadó, vol. 105(1), pages 611-622, October.
    2. Sardorbek Musayev & Jonathan Mellor & Tara Walsh & Emmanouil Anagnostou, 2021. "Development of an Agent-Based Model for Weather Forecast Information Exchange in Rural Area of Bahir Dar, Ethiopia," Sustainability, MDPI, vol. 13(9), pages 1-21, April.
    3. Ngo-Hoang, Dai-Long, 2019. "A research paper of Hossein Sabzian (2019), Theories and Practice of Agent based Modeling: Some practical Implications for Economic Planners, ArXiv, 54p," AgriXiv xutyz_v1, Center for Open Science.
    4. Talal Daghriri & Michael Proctor & Sarah Matthews, 2022. "Evolution of Select Epidemiological Modeling and the Rise of Population Sentiment Analysis: A Literature Review and COVID-19 Sentiment Illustration," IJERPH, MDPI, vol. 19(6), pages 1-20, March.
    5. Hossein Sabzian & Mohammad Ali Shafia & Ali Maleki & Seyeed Mostapha Seyeed Hashemi & Ali Baghaei & Hossein Gharib, 2019. "Theories and Practice of Agent based Modeling: Some practical Implications for Economic Planners," Papers 1901.08932, arXiv.org.
    6. Navonil Mustafee & Korina Katsaliaki & Paul Fishwick, 2014. "Exploring the modelling and simulation knowledge base through journal co-citation analysis," Scientometrics, Springer;Akadémiai Kiadó, vol. 98(3), pages 2145-2159, March.
    7. Omkar Joshi & Rodney E. Will & Chris B. Zou & Gehendra Kharel, 2019. "Sustaining Cross-Timbers Forest Resources: Current Knowledge and Future Research Needs," Sustainability, MDPI, vol. 11(17), pages 1-12, August.
    8. Bernardo A. Furtado & Miguel A. Fuentes & Claudio J. Tessone, 2019. "Policy Modeling and Applications: State-of-the-Art and Perspectives," Complexity, Hindawi, vol. 2019, pages 1-11, February.
    9. Viet-Cuong Trieu & Fu-Ren Lin, 2022. "The Development of a Service System for Facilitating Food Resource Allocation and Service Exchange," Sustainability, MDPI, vol. 14(19), pages 1-29, September.
    10. Gao, Lin, 2017. "Between Trust and Performance: Exploring Socio-Economic Mechanisms on Directed Weighted Regular Ring with Agent-Based Modeling," MPRA Paper 78428, University Library of Munich, Germany.
    11. Ngo-Hoang, Dai-Long, 2019. "A research paper of Hossein Sabzian (2019), Theories and Practice of Agent based Modeling: Some practical Implications for Economic Planners, ArXiv, 54p," AgriXiv xutyz, Center for Open Science.
    12. Shaojie Qi & Fengrui Hua & Zheng Zhou & Daniel T. L. Shek, 2022. "Trends of Positive Youth Development Publications (1995–2020): A Scientometric Review," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 17(1), pages 421-446, February.
    13. Yaozong Zhu & Yezhu Wang & Baohuan Zhou & Xiaoli Hu & Yundong Xie, 2023. "A Patent Bibliometric Analysis of Carbon Capture, Utilization, and Storage (CCUS) Technology," Sustainability, MDPI, vol. 15(4), pages 1-20, February.
    14. Guifeng Liu, 2013. "Visualization of patents and papers in terahertz technology: a comparative study," Scientometrics, Springer;Akadémiai Kiadó, vol. 94(3), pages 1037-1056, March.
    15. Mohammad Vahidnia & Ali Alesheikh & Seyed Alavipanah, 2015. "A multi-agent architecture for geosimulation of moving agents," Journal of Geographical Systems, Springer, vol. 17(4), pages 353-390, October.
    16. Biola K. Badmos & Sampson K. Agodzo & Grace B. Villamor & Samuel N. Odai, 2015. "An Approach for Simulating Soil Loss from an Agro-Ecosystem Using Multi-Agent Simulation: A Case Study for Semi-Arid Ghana," Land, MDPI, vol. 4(3), pages 1-20, July.
    17. Xiaoling Wang & Jatin Nathwani & Chunyou Wu, 2016. "Visualization of International Energy Policy Research," Energies, MDPI, vol. 9(2), pages 1-14, January.
    18. Hu, Maomao & Xiao, Fu & Wang, Shengwei, 2021. "Neighborhood-level coordination and negotiation techniques for managing demand-side flexibility in residential microgrids," Renewable and Sustainable Energy Reviews, Elsevier, vol. 135(C).
    19. Fetta, Angelico & Harper, Paul & Knight, Vincent & Williams, Janet, 2018. "Predicting adolescent social networks to stop smoking in secondary schools," European Journal of Operational Research, Elsevier, vol. 265(1), pages 263-276.
    20. Dániel Tokody & Mária Tor & Endre Szûcs & Francesco Flammini & Laszlo Barna Iantovics, 2018. "On the Development of Intelligent Railway Information and Safety Systems: An Overview of Current Research," Interdisciplinary Description of Complex Systems - scientific journal, Croatian Interdisciplinary Society Provider Homepage: http://indecs.eu, vol. 16(1), pages 176-185.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0094411. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.