IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0090947.html
   My bibliography  Save this article

Assessing the Impact of Copy Number Variants on miRNA Genes in Autism by Monte Carlo Simulation

Author

Listed:
  • Maurizio Marrale
  • Nadia Ninfa Albanese
  • Francesco Calì
  • Valentino Romano

Abstract

Autism Spectrum Disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies have investigated the role of de novo Copy Number Variants (CNVs) and microRNAs as important but distinct etiological factors in ASD. We developed a novel computational procedure to assess the potential pathogenic role of microRNA genes overlapping de novo CNVs in ASD patients. Here we show that for chromosomes # 1, 2 and 22 the actual number of miRNA loci affected by de novo CNVs in patients was found significantly higher than that estimated by Monte Carlo simulation of random CNV events. Out of 24 miRNA genes over-represented in CNVs from these three chromosomes only hsa-mir-4436b-1 and hsa-mir-4436b-2 have not been detected in CNVs from non-autistic subjects as reported in the Database of Genomic Variants. Altogether the results reported in this study represent a first step towards a full understanding of how a dysregulated expression of the 24 miRNAs genes affect neurodevelopment in autism. We also propose that the procedure used in this study can be effectively applied to CNVs/miRNA genes association data in other genomic disorders beyond autism.

Suggested Citation

  • Maurizio Marrale & Nadia Ninfa Albanese & Francesco Calì & Valentino Romano, 2014. "Assessing the Impact of Copy Number Variants on miRNA Genes in Autism by Monte Carlo Simulation," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0090947
    DOI: 10.1371/journal.pone.0090947
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090947
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090947&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0090947?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Yoontae Lee & Chiyoung Ahn & Jinju Han & Hyounjeong Choi & Jaekwang Kim & Jeongbin Yim & Junho Lee & Patrick Provost & Olof Rådmark & Sunyoung Kim & V. Narry Kim, 2003. "The nuclear RNase III Drosha initiates microRNA processing," Nature, Nature, vol. 425(6956), pages 415-419, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mu-Peng Li & Yao-Dong Hu & Xiao-Lei Hu & Yan-Jiao Zhang & Yong-Long Yang & Chun Jiang & Jie Tang & Xiao-Ping Chen, 2016. "MiRNAs and miRNA Polymorphisms Modify Drug Response," IJERPH, MDPI, vol. 13(11), pages 1-22, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jun Wang & Jinyong Huang & Yunlong Hu & Qianwen Guo & Shasha Zhang & Jinglin Tian & Yanqin Niu & Ling Ji & Yuzhong Xu & Peijun Tang & Yaqin He & Yuna Wang & Shuya Zhang & Hao Yang & Kang Kang & Xinchu, 2024. "Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Xiaorong Yang & Yanan Guo & Yane Du & Jinmei Yang & Shichao Li & Shengnan Liu & Ke Li & Dechun Zhang, 2014. "Serum MicroRNA-21 as a Diagnostic Marker for Lung Carcinoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.
    3. Le Thi Truc Linh, 2018. "The Microrna 29 family and its regulation," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 8(1), pages 18-27.
    4. Paola Mozzoni & Diana Poli & Silvana Pinelli & Sara Tagliaferri & Massimo Corradi & Delia Cavallo & Cinzia Lucia Ursini & Daniela Pigini, 2023. "Benzene Exposure and MicroRNAs Expression: In Vitro, In Vivo and Human Findings," IJERPH, MDPI, vol. 20(3), pages 1-16, January.
    5. Lingzi Xia & Yangwu Ren & Xue Fang & Zhihua Yin & Xuelian Li & Wei Wu & Peng Guan & Baosen Zhou, 2014. "Prognostic Role of Common MicroRNA Polymorphisms in Cancers: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-8, October.
    6. Ying Wang & Xiushan Zheng & Zhiyong Zhang & Jinfeng Zhou & Guohong Zhao & Jianjun Yang & Limin Xia & Rui Wang & Xiqiang Cai & Hao Hu & Cailin Zhu & Yongzhan Nie & Kaichun Wu & Dexin Zhang & Daiming Fa, 2012. "MicroRNA-149 Inhibits Proliferation and Cell Cycle Progression through the Targeting of ZBTB2 in Human Gastric Cancer," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-10, October.
    7. Bin Liu & Longyun Fang & Fule Liu & Xiaolong Wang & Junjie Chen & Kuo-Chen Chou, 2015. "Identification of Real MicroRNA Precursors with a Pseudo Structure Status Composition Approach," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-20, March.
    8. Sofia Khan & Dario Greco & Kyriaki Michailidou & Roger L Milne & Taru A Muranen & Tuomas Heikkinen & Kirsimari Aaltonen & Joe Dennis & Manjeet K Bolla & Jianjun Liu & Per Hall & Astrid Irwanto & Keith, 2014. "MicroRNA Related Polymorphisms and Breast Cancer Risk," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-11, November.
    9. Guangwen Long & Feng Wang & Quanlu Duan & Shenglan Yang & Fuqiong Chen & Wei Gong & Xu Yang & Yan Wang & Chen Chen & Dao Wen Wang, 2012. "Circulating miR-30a, miR-195 and let-7b Associated with Acute Myocardial Infarction," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-8, December.
    10. San-Nung Chen & Renin Chang & Li-Te Lin & Chyi-Uei Chern & Hsiao-Wen Tsai & Zhi-Hong Wen & Yi-Han Li & Chia-Jung Li & Kuan-Hao Tsui, 2019. "MicroRNA in Ovarian Cancer: Biology, Pathogenesis, and Therapeutic Opportunities," IJERPH, MDPI, vol. 16(9), pages 1-14, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0090947. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.