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MiRNAs and miRNA Polymorphisms Modify Drug Response

Author

Listed:
  • Mu-Peng Li

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Yao-Dong Hu

    (Department of Cardiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China)

  • Xiao-Lei Hu

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Yan-Jiao Zhang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Yong-Long Yang

    (Haikou People’s Hospital and Affiliated Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570311, China)

  • Chun Jiang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Jie Tang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Xiao-Ping Chen

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

Abstract

Differences in expression of drug response-related genes contribute to inter-individual variation in drugs’ biological effects. MicroRNAs (miRNAs) are small noncoding RNAs emerging as new players in epigenetic regulation of gene expression at post-transcriptional level. MiRNAs regulate the expression of genes involved in drug metabolism, drug transportation, drug targets and downstream signal molecules directly or indirectly. MiRNA polymorphisms, the genetic variations affecting miRNA expression and/or miRNA-mRNA interaction, provide a new insight into the understanding of inter-individual difference in drug response. Here, we provide an overview of the recent progress in miRNAs mediated regulation of biotransformation enzymes, drug transporters, and nuclear receptors. We also describe the implications of miRNA polymorphisms in cancer chemotherapy response.

Suggested Citation

  • Mu-Peng Li & Yao-Dong Hu & Xiao-Lei Hu & Yan-Jiao Zhang & Yong-Long Yang & Chun Jiang & Jie Tang & Xiao-Ping Chen, 2016. "MiRNAs and miRNA Polymorphisms Modify Drug Response," IJERPH, MDPI, vol. 13(11), pages 1-22, November.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:11:p:1096-:d:82389
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    References listed on IDEAS

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    1. Alfons Navarro & Carmen Muñoz & Anna Gaya & Marina Díaz-Beyá & Bernat Gel & Rut Tejero & Tania Díaz & Antonio Martinez & Mariano Monzó, 2013. "MiR-SNPs as Markers of Toxicity and Clinical Outcome in Hodgkin Lymphoma Patients," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.
    2. Maurizio Marrale & Nadia Ninfa Albanese & Francesco Calì & Valentino Romano, 2014. "Assessing the Impact of Copy Number Variants on miRNA Genes in Autism by Monte Carlo Simulation," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-10, March.
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