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NOD2 Polymorphisms Associated with Cancer Risk: A Meta-Analysis

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  • Jingwei Liu
  • Caiyun He
  • Qian Xu
  • Chengzhong Xing
  • Yuan Yuan

Abstract

Background: Emerging evidence indicated that common polymorphisms of NOD2 might impact individual susceptibility to cancer. However, the results from published studies were inconclusive. The aim of this meta-analysis was to elucidate whether NOD2 polymorphisms were associated with cancer risk. Methods: A systematically literature search was performed by using electronic databases including PubMed and Web of Science. ORs and their 95% CI were used to assess the strength of association between NOD2 gene polymorphisms and cancer risks. Results: Thirty case-control studies were included in this meta-analysis. The pooled analysis indicated that NOD2 rs2066842 C/T polymorphism was not significantly associated with cancer risk; for NOD2 rs2066844 C/T polymorphism, (TT+CT) genotype was associated with increased cancer risk compared with wild-type CC genotype (OR = 1.32, 95% CI = 1.01–1.72, P = 0.041); for NOD2 rs2066845 C/G polymorphism, individuals with (CC+CG) genotype were significantly associated with increased cancer risk compared with GG genotype (OR = 1.32, 95% CI = 1.01–1.72, P = 0.040); for NOD2 rs2066847 (3020insC) polymorphism, carriers of (insC/insC+insC/−) genotype were significantly associated with increased cancer risk compared with −/− carriers (OR = 1.23, 95% CI = 1.10–1.38, P

Suggested Citation

  • Jingwei Liu & Caiyun He & Qian Xu & Chengzhong Xing & Yuan Yuan, 2014. "NOD2 Polymorphisms Associated with Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-10, February.
    • Handle: RePEc:plo:pone00:0089340
    DOI: 10.1371/journal.pone.0089340
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    References listed on IDEAS

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    1. Yasunori Ogura & Denise K. Bonen & Naohiro Inohara & Dan L. Nicolae & Felicia F. Chen & Richard Ramos & Heidi Britton & Thomas Moran & Reda Karaliuskas & Richard H. Duerr & Jean-Paul Achkar & Steven R, 2001. "A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease," Nature, Nature, vol. 411(6837), pages 603-606, May.
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