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Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities – A Population Based Cohort Study

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  • Alison D Murray
  • Christopher J McNeil
  • Sima Salarirad
  • Lawrence J Whalley
  • Roger T Staff

Abstract

Context: There have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear. Objective: To test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect. Design: Cohort study Setting: Community Participants: 227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia. Main Outcome Measures: Relationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities. Results: We find significant negative correlations between childhood socioeconomic circumstance and white matter hyperintensities (ρ = −0.18, P

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  • Alison D Murray & Christopher J McNeil & Sima Salarirad & Lawrence J Whalley & Roger T Staff, 2014. "Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities – A Population Based Cohort Study," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-7, February.
    • Handle: RePEc:plo:pone00:0088969
    DOI: 10.1371/journal.pone.0088969
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    References listed on IDEAS

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    1. Power, C. & Hyppönen, E. & Smith, G.D., 2005. "Socioeconomic position in childhood and early adult life and risk of mortality: A prospective study of the mothers of the 1958 British birth cohort," American Journal of Public Health, American Public Health Association, vol. 95(8), pages 1396-1402.
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