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Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients

Author

Listed:
  • Georgios Grammatikos
  • Christian Lange
  • Simone Susser
  • Susanne Schwendy
  • Nektarios Dikopoulos
  • Peter Buggisch
  • Jens Encke
  • Gerlinde Teuber
  • Tobias Goeser
  • Robert Thimme
  • Hartwig Klinker
  • Wulf O Boecher
  • Ewert Schulte-Frohlinde
  • Marissa Penna-Martinez
  • Klaus Badenhoop
  • Stefan Zeuzem
  • Thomas Berg
  • Christoph Sarrazin

Abstract

Background: Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed. Methods: In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-α and ribavirin for 24–72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome. Results: Fluctuations of more than 5 (10) ng/ml in 25-OH-vitamin D-levels have been observed in 66 (39) % of patients during the course of antiviral therapy and neither pretreatment nor under treatment 25-OH-vitamin D-levels were associated with treatment outcome. The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. Among numerous further parameters analyzed we found that age (OR = 1.028, CI = 1.002–1.056, P = 0.035), cholesterol (OR = 0.983, CI = 0.975–0.991, P

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  • Georgios Grammatikos & Christian Lange & Simone Susser & Susanne Schwendy & Nektarios Dikopoulos & Peter Buggisch & Jens Encke & Gerlinde Teuber & Tobias Goeser & Robert Thimme & Hartwig Klinker & Wul, 2014. "Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-9, February.
    • Handle: RePEc:plo:pone00:0087974
    DOI: 10.1371/journal.pone.0087974
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    1. Dongliang Ge & Jacques Fellay & Alexander J. Thompson & Jason S. Simon & Kevin V. Shianna & Thomas J. Urban & Erin L. Heinzen & Ping Qiu & Arthur H. Bertelsen & Andrew J. Muir & Mark Sulkowski & John , 2009. "Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance," Nature, Nature, vol. 461(7262), pages 399-401, September.
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