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Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

Author

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  • Dongliang Ge

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Jacques Fellay

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Alexander J. Thompson

    (School of Medicine, Duke University, Durham, North Carolina 27705, USA)

  • Jason S. Simon

    (Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA)

  • Kevin V. Shianna

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Thomas J. Urban

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Erin L. Heinzen

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Ping Qiu

    (Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA)

  • Arthur H. Bertelsen

    (Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA)

  • Andrew J. Muir

    (School of Medicine, Duke University, Durham, North Carolina 27705, USA)

  • Mark Sulkowski

    (Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • John G. McHutchison

    (School of Medicine, Duke University, Durham, North Carolina 27705, USA)

  • David B. Goldstein

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

Abstract

Individual responses to hepatitis C virus Hepatitis C is one of the most common infections in the world. Many of its estimated 170 million sufferers live with the disease for years with no serious symptoms, but in about one in four patients it leads to cirrhosis of the liver. The discovery of a biomarker that predicts an individual's response to hepatitis C treatment raises the possibility that clinical outcomes could be improved by raising patient compliance to the often demanding interferon treatment regime. The new marker is a 'single letter' genetic variant — a C (cytosine) replacing a T (thymidine) in a segment of DNA near the IL28B gene that encodes interleukin 28B (interferon-γ-3). This finding goes some way towards explaining the different treatment outcomes between individuals of European (high IL28B frequency), African and Asian ancestry. And importantly, it is of immediate clinical utility.

Suggested Citation

  • Dongliang Ge & Jacques Fellay & Alexander J. Thompson & Jason S. Simon & Kevin V. Shianna & Thomas J. Urban & Erin L. Heinzen & Ping Qiu & Arthur H. Bertelsen & Andrew J. Muir & Mark Sulkowski & John , 2009. "Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance," Nature, Nature, vol. 461(7262), pages 399-401, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7262:d:10.1038_nature08309
    DOI: 10.1038/nature08309
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